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首页> 外文期刊>Cell and Tissue Research >Osteoblast ontogeny and implications for bone pathology: An overview
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Osteoblast ontogeny and implications for bone pathology: An overview

机译：成骨细胞个体发育及其对骨病理学的影响：概述

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摘要

Osteoblasts are specialized mesenchyme-derived cells accountable for bone synthesis, remodelling and healing. Differentiation of osteoblasts from mesenchymal stem cells (MSC) towards osteocytes is a multi-step process strictly controlled by various genes, transcription factors and signalling proteins. The aim of this review is to provide an update on the nature of bone-forming osteoblastic cells, highlighting recent data on MSC - osteoblast - osteocyte transformation from a molecular perspective and to discuss osteoblast malfunctions in various bone diseases. We present here the consecutive stages occurring in the differentiation of osteoblasts from MSC, the transcription factors involved and the role of miRNAs in the process. Recent data concerning the pathogenic mechanisms underlying the loss of bone mass and architecture caused by malfunctions in the synthetic activity and metabolism of osteoblasts in osteoporosis, osteogenesis imperfecta, osteoarthritis and rheumatoid arthritis are discussed. The newly acquired knowledge of the ontogeny of osteoblasts will assist in unravelling the abnormalities taking place during their differentiation and will facilitate the prevention and/or treatment of bone diseases by therapy directed against altered molecules and mechanisms.
机译：成骨细胞是专门的间充质来源的细胞，负责骨骼的合成，重塑和愈合。成骨细胞从间充质干细胞（MSC）向骨细胞的分化是一个多步过程，受多种基因，转录因子和信号蛋白严格控制。这篇综述的目的是提供有关成骨性成骨细胞的性质的最新信息，从分子角度突出有关MSC-成骨细胞-骨细胞转化的最新数据，并讨论各种骨疾病中成骨细胞的功能障碍。我们在这里介绍了从MSC分化为成骨细胞，发生的转录因子和miRNA在该过程中的作用的连续阶段。讨论了有关骨质疏松症，成骨不全症，骨关节炎和类风湿性关节炎中成骨细胞合成活性和代谢功能异常引起的骨量和结构丧失的致病机制的最新数据。对成骨细胞的个体发育的新获得的知识将有助于弄清它们分化期间发生的异常，并且将通过针对改变的分子和机制的疗法来促进骨疾病的预防和/或治疗。

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