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首页> 外文期刊>Cellular immunology >Increased immunosuppressive treatment combined with unrelated umbilical cord blood infusion in children with severe aplastic anemia
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Increased immunosuppressive treatment combined with unrelated umbilical cord blood infusion in children with severe aplastic anemia

机译：严重再生障碍性贫血儿童的免疫抑制治疗增加与无关脐带血输注

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A combination treatment of unrelated umbilical cord blood (UCB) and increased immunosuppressive treatment (IST) were investigated to reveal the potentially curative therapy for the severe aplastic anemia (SAA). A total of 36 children (2-17 ages) with SAA who received UCB infusion after an IST were analyzed. The treatment consisted of 100. mg/kg cyclophosphamide, 12.5-15. mg/kg antithymocyte globulin and 3. mg/kg cyclosporine. After 3. months, the hematologic complete response (CR) rate was 22.2% and partial response (PR) rate was 38.9%. After 6. months, the CR rate and PR rate was 50.4% and 26.3%, respectively. The probability of 3-year survival was 83.3%. There was no difference in the survival rate either between the horse-ATG and rabbit-ATG or between the SAA and VSAA. The results indicated that the increased IST combined with unrelated UCB infusion has an effective therapeutic potential for children with SAA who lack of compatible donor for transplantation.
机译：研究了不相关的脐带血（UCB）和增强的免疫抑制治疗（IST）的联合治疗，以揭示重度再生障碍性贫血（SAA）的潜在治疗方法。分析了总共36例SAA患儿（2-17岁），在IST后接受UCB输液。处理由100. mg / kg环磷酰胺12.5-15组成。 mg / kg抗胸腺细胞球蛋白和3. mg / kg环孢素。 3个月后，血液学完全缓解（CR）率为22.2％，部分缓解（PR）率为38.9％。 6个月后，CR率和PR率分别为50.4％和26.3％。 3年生存率是83.3％。马ATG和兔ATG之间或SAA和VSAA之间的存活率没有差异。结果表明，增加的IST结合无关的UCB输注对于缺乏适合的供体移植的SAA儿童具有有效的治疗潜力。

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