Human CD8+ T cells display a differential ability to undergo cytokine-driven bystander activation.

Bou Ghanem EN; DOrazio SE

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Human CD8+ T cells display a differential ability to undergo cytokine-driven bystander activation.

机译：人类CD8 + T细胞显示出受细胞因子驱动的旁观者激活的差异能力。

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A subset of CD44(hi)CD8+ T cells in some, but not all mice, can be induced to rapidly secrete IFNgamma during infection with Listeria monocytogenes. This response is dependent on the presence of both IL-12 and IL-18 and does not require engagement of the T cell receptor. In this study, we demonstrate that human CD8+ T cells also vary widely in their ability to secrete IFNgamma within 15h of either Listeria infection or cytokine stimulation. The magnitude of the rapid IFNgamma response correlated more closely with the intrinsic responsiveness of the T cells to cytokine stimulation rather than the amount of IL-12 produced. CD8+ T cells from 2 out of 16 blood donors (12.5%) failed to generate a significant IFNgamma response. These results demonstrate that bystander activation of CD8+ T cells varies among individuals and validate further study of the differential responses observed using BALB/c vs. C57BL/6 mice.

机译：在某些（但不是全部）小鼠中，CD44（hi）CD8 + T细胞的一个亚群可被李斯特菌感染期间迅速分泌IFNγ。该反应取决于IL-12和IL-18的存在，并且不需要T细胞受体的参与。在这项研究中，我们证明了人类CD8 + T细胞在李斯特菌感染或细胞因子刺激后15小时内分泌IFNgamma的能力也存在很大差异。快速IFNγ反应的强度与T细胞对细胞因子刺激的内在反应性更紧密相关，而不是与产生的IL-12的量更紧密相关。 16个献血者中有2个（12.5％）的CD8 + T细胞未能产生明显的IFNγ反应。这些结果表明，CD8 + T细胞的旁观者激活在个体之间是不同的，并验证了使用BALB / c与C57BL / 6小鼠观察到的差异反应的进一步研究。

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《Cellular immunology》 |2011年第1期|共8页
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Bou Ghanem EN; DOrazio SE;
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中图分类细胞生物学;
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Human CD8+ T cells display a differential ability to undergo cytokine-driven bystander activation.

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