...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >A role for polyamine regulators in ESC self-renewal
【24h】

A role for polyamine regulators in ESC self-renewal

机译：多胺调节剂在ESC自我更新中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Embryonic stem cells (ESCs) depend on extensive regulatory networks to coordinate their self-renewal and differentiation. The polyamine pathway regulator AMD1 was recently implicated in ESC self-renewal and directed differentiation of ESCs to neural precursor cells (NPCs). The polyamines spermine and spermidine are essential for a wide range of biological processes, and their levels are tightly regulated. Here, we review the polyamine pathway and discuss how it can impact polyamine levels, cellular methylation and hypusinated EIF5A levels. We discuss how it could feed into regulation of ESC self-renewal and directed differentiation. We show that in addition to AMD1, a second rate-limiting enzyme in the polyamine pathway, ODC1, can also promote ESC self-renewal, and that both Amd1 and Odc1 can partially substitute for Myc during cellular reprogramming. We propose that both Amd1 and Odc1 are essential regulators of ESCs and function to ensure high polyamine levels to promote ESC self-renewal. 2012;
机译：胚胎干细胞（ESC）依赖于广泛的调节网络来协调其自我更新和分化。最近，多胺途径调节剂AMD1参与了ESC自我更新和ESC向神经前体细胞（NPC）的定向分化。多胺精胺和亚精胺对于许多生物学过程都是必不可少的，并且其含量受到严格调节。在这里，我们回顾了多胺途径，并讨论了它如何影响多胺水平，细胞甲基化和羟化的EIF5A水平。我们讨论了如何将其用于调节ESC自我更新和定向分化。我们显示，除了AMD1之外，多胺途径ODC1中的第二个限速酶也可以促进ESC自我更新，并且在细胞重编程过程中Amd1和Odc1都可以部分替代Myc。我们建议，Amd1和Odc1都是ESC的重要调节剂，并具有确保高多胺水平以促进ESC自我更新的功能。 2012;

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号