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首页> 外文期刊>Lupus >Long-term membranous glomerulonephritis as the presenting manifestation of systemic lupus erythematosus in a patient with human immunodeficiency virus infection
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Long-term membranous glomerulonephritis as the presenting manifestation of systemic lupus erythematosus in a patient with human immunodeficiency virus infection

机译：长期膜性肾小球肾炎是人类免疫缺陷病毒感染患者系统性红斑狼疮的表现

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The coexistence of human immunodeficiency virus (HIV) infection and systemic lupus erythematosus (SLE) is unusual, but the occurrence of SLE after HIV infection is even less common. Both conditions share similar clinical features including constitutional symptoms, facial rash, oral ulcers, alopecia, arthralgias, arthritis, seizures, cytopenias, glomerulonephritis, and antinuclear and antiphospholipid antibodies. This clinical overlap makes the diagnosis of SLE in a patient with pre-existing HIV infection difficult. Furthermore, immune complex glomerulonephritis with features resembling lupus nephritis has been described in HIV-positive patients. We present the case of a 45-year-old Hispanic woman with long-standing HIV infection who developed membranous glomerulonephritis with histological features of lupus nephritis. Five years after onset of renal disease she developed clinically evident SLE.
机译：人类免疫缺陷病毒（HIV）感染和系统性红斑狼疮（SLE）并存是罕见的，但是在HIV感染后发生SLE的情况更为罕见。两种疾病都有相似的临床特征，包括体质症状，面部皮疹，口腔溃疡，脱发，关节痛，关节炎，癫痫发作，血细胞减少，肾小球肾炎以及抗核和抗磷脂抗体。这种临床重叠使先前存在HIV感染的患者难以诊断SLE。此外，已经在HIV阳性患者中描述了具有类似于狼疮肾炎的特征的免疫复合物肾小球肾炎。我们介绍了一个患有艾滋病毒长期感染的45岁西班牙裔妇女的案例，该妇女发展了具有狼疮性肾炎组织学特征的膜性肾小球肾炎。肾脏疾病发作五年后，她发展出临床上明显的SLE。

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