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首页> 外文期刊>Cellular immunology >Prostaglandin E2 suppresses beta1-integrin expression via E-prostanoid receptor in human monocytes/macrophages.
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Prostaglandin E2 suppresses beta1-integrin expression via E-prostanoid receptor in human monocytes/macrophages.

机译：前列腺素E2通过人类单核细胞/巨噬细胞中的E-前列腺素受体抑制β1-整合素的表达。

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摘要

Beta1-integrins mediate cell attachment to different extracellular matrix proteins, intracellular proteins, and intercellular adhesions. Recently, it has been reported that prostaglandin E2 (PGE2) has anti-inflammatory properties such as inhibition of the expression of adhesion molecules or production of chemokines. However, the effect of PGE2 on the expression of beta1-integrin remains unknown. In this study, we investigated the effects of PGE2 on the expression of beta1-integrin in the human monocytic cell line THP-1 and in CD14+ monocytes/macrophages in human peripheral blood. For this, we examined the role of four subtypes of PGE2 receptors and E-prostanoid (EP) receptors on PGE2-mediated inhibition. We found that PGE2 significantly inhibited the expression of beta1-integrin, mainly through EP4 receptors in THP-1 cells and CD14+ monocytes/macrophages in human peripheral blood. We suggest that PGE2 has anti-inflammatory effects, leading to the inhibited expression of beta1-integrin in human monocytes/macrophages, and that the EP4 receptor may play an important role in PGE2-mediated inhibition.
机译：Beta1整合素介导细胞附着于不同的细胞外基质蛋白，细胞内蛋白和细胞间粘附。最近，已经报道前列腺素E2（PGE2）具有抗炎特性，例如抑制粘附分子的表达或趋化因子的产生。但是，PGE2对β1-整合素表达的影响仍然未知。在这项研究中，我们调查了PGE2对人单核细胞THP-1和人外周血CD14 +单核细胞/巨噬细胞中β1-整合素表达的影响。为此，我们检查了PGE2受体和E-前列腺素（EP）受体的四种亚型对PGE2介导的抑制作用。我们发现PGE2主要通过THP-1细胞中的EP4受体和人外周血中的CD14 +单核细胞/巨噬细胞显着抑制β1-整合素的表达。我们建议PGE2具有抗炎作用，导致人类单核细胞/巨噬细胞中β1-整合素的表达受到抑制，并且EP4受体可能在PGE2介导的抑制中起重要作用。

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