...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Lupus >From autoantibody research to standardized diagnostic assays in the management of human diseases - report of the 12th Dresden Symposium on Autoantibodies
【24h】

From autoantibody research to standardized diagnostic assays in the management of human diseases - report of the 12th Dresden Symposium on Autoantibodies

机译：从人类抗体研究到人类疾病管理中的标准化诊断测定法-第十二届德累斯顿自身抗体研讨会报告

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Testing for autoantibodies (AABs) is becoming more and more relevant, not only for diagnosing autoimmune diseases (AIDs) but also for the differentiation of defined AID subtypes with different clinical manifestations, course and prognosis as well as the very early diagnosis for adequate management in the context of personalized medicine. A major challenge to improve diagnostic accuracy is to harmonize or even standardize AAB analyses. This review presents the results of the 12th Dresden Symposium on Autoantibodies that focused on several aspects of improving autoimmune diagnostics. Topics that are addressed include the International Consensus on ANA Patterns (ICAP) and the International Autoantibody Standardization (IAS) initiatives, the optimization of diagnostic algorithms, the description and evaluation of novel disease-specific AABs as well as the development and introduction of novel assays into routine diagnostics. This review also highlights important developments of recent years, most notably the improvement in diagnosing and predicting the course of rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies, and of autoimmune neurological, gastrointestinal and liver diseases; the potential diagnostic role of anti-DFS70 antibodies and tumor-associated AABs. Furthermore, some hot topics in autoimmunity regarding disease pathogenesis and management are described.
机译：自身抗体（AAB）的检测变得越来越重要，不仅用于诊断自身免疫性疾病（AID），而且还用于区分具有不同临床表现，病程和预后的已定义AID亚型，以及为尽早进行适当管理而进行的早期诊断。个性化医学的背景。提高诊断准确性的主要挑战是协调或什至标准化AAB分析。这篇综述介绍了第十二届德累斯顿自身抗体研讨会的结果，该研讨会的重点是改善自身免疫诊断的几个方面。讨论的主题包括国际ANA模式共识（ICAP）和国际自身抗体标准化（IAS）计划，诊断算法的优化，新型疾病特异性AAB的描述和评估以及新型测定的开发和引入进入常规诊断。这篇综述还着重介绍了近年来的重要发展，尤其是在诊断和预测类风湿性关节炎，全身性硬化症，特发性炎症性肌病以及自身免疫性神经，胃肠道和肝脏疾病的过程方面的改进;抗DFS70抗体和与肿瘤相关的AAB的潜在诊断作用。此外，描述了自身免疫中有关疾病发病机理和治疗的一些热门话题。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号