...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >Immunological consequences of macrophage-mediated clearance of apoptotic cells.
【24h】

Immunological consequences of macrophage-mediated clearance of apoptotic cells.

机译：巨噬细胞介导的凋亡细胞清除的免疫学后果。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Apoptosis and the rapid clearance of apoptotic cells by professional or nonprofessional phagocytes are normal and coordinated processes that ensure controlled cell growth with a nonpathological outcome. Defects in clearance of apoptotic cells by macrophages have serious consequences often resulting in autoimmune disorders. Phagocyte-derived immunoregulatory cytokines such as Interleukin-12 and Interleukin-10 play pivotal roles in the etiology and pathology of many autoimmune diseases. Elucidation of the apoptotic cell-mediated signaling mechanisms involved in the control of pro- and anti-inflammatory cytokines during cell turnovers under normal and pathological conditions may help us counter the cytokine dysregulation and control inappropriate host immune reactions in pathological situations such as autoimmunity, infectious diseases, graft-versus-host disease, and cancer.
机译：专业或非专业吞噬细胞的凋亡和凋亡细胞的快速清除是正常且协调一致的过程，可确保受控的细胞生长且具有非病理结果。巨噬细胞清除凋亡细胞的缺陷具有严重后果，通常会导致自身免疫疾病。吞噬细胞衍生的免疫调节细胞因子（例如白细胞介素12和白细胞介素10）在许多自身免疫性疾病的病因和病理中起关键作用。阐明在正常和病理条件下细胞更新过程中控制促炎和抗炎细胞因子的凋亡细胞介导的信号传导机制可能有助于我们应对细胞因子失调，并在病理情况下（例如自身免疫性，传染性）控制不适当的宿主免疫反应疾病，移植物抗宿主病和癌症。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号