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Stimulation of the exocrine pancreas via a third CCK-receptor subtype?

机译：通过第三种CCK受体亚型刺激外分泌胰腺？

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The physiological role of the cholecystokininl receptor (CCK1R) and the cholecystokinin/gastrin receptor (CCK2R) in the enzyme release from the exocrine pancreas in various mammal species has been debated. Experiments in pigs have indicated that physiological levels of cholecystokinin-33 (CCK-33) elicit pancreatic enzyme release via CCK2Rs located in the gastro-duodenal region. Since gastrin and CCK have similar affinity for the CCK2R, the aim was to examine if gastrin can elicit a similar enzyme response as CCK, after infusion via the gastric artery. Weaned pigs were anaesthetised and surgically prepared with appropriate catheters. Pentagastrin (n=6) or CCK-33 (n=6), 13 pmol/kg, was infused via the gastric artery into the gastro-duodenal region and20 min. later 130 pmol/kg of the same hormone was infused via the jugular vein to the general circulation. Pancreatic juice was collected in intervals after each infusion and analysed for its protein and enzyme (trypsin) content. CCK-33 gave rise to significantly higher protein and trypsin output compared to pentagastrin for both doses and infusion routes. The results indicate that low doses of CCK-33 infused to the duodenal region do not stimulate the exocrine pancreas via the CCK2R since the result can't be reproduced with pentagastrin. Since previous studies have indicated that CCK1R is not involved the present results indicate that a third CCK-receptor subtype might be involved in the stimulation of the exocrine pancreas.
机译：胆囊收缩素受体（CCK1R）和胆囊收缩素/胃泌素受体（CCK2R）在各种哺乳动物物种的外分泌胰腺释放酶中的生理作用已受到争议。猪实验表明，生理水平的胆囊收缩素-33（CCK-33）通过位于胃十二指肠区域的CCK2Rs引起胰腺酶释放。由于胃泌素和CCK对CCK2R具有相似的亲和力，因此目的是检查通过胃动脉输注后胃泌素是否能够引发与CCK类似的酶反应。对断奶的猪进行麻醉，并用适当的导管进行手术准备。经由胃动脉将五肽胃泌素（n = 6）或CCK-33（n = 6）13 pmol / kg注入胃十二指肠区域，持续20分钟。之后，通过颈静脉将130 pmol / kg的相同激素注入全身循环。每次输注后要定期收集胰液，并分析其蛋白质和酶（胰蛋白酶）含量。在剂量和输注途径上，与五肽胃泌素相比，CCK-33产生的蛋白质和胰蛋白酶产量明显更高。结果表明，低剂量的CCK-33输注到十二指肠区域不会通过CCK2R刺激外分泌胰腺，因为该结果不能由五肽胃泌素复制。由于先前的研究表明不参与CCK1R，因此本研究结果表明第三种CCK受体亚型可能与外分泌胰腺的刺激有关。

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