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首页> 外文期刊>Livestock Science >Relationship between genealogical and microsatellite information characterizing losses of genetic variability: Empirical evidence from the rare Xalda sheep breed
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Relationship between genealogical and microsatellite information characterizing losses of genetic variability: Empirical evidence from the rare Xalda sheep breed

机译：表征遗传变异性损失的家谱信息与微卫星信息之间的关系：稀有的Xalda绵羊品种的经验证据

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摘要

Preservation of rare genetic stocks requires continual monitoring of populations to avoid losses of genetic variability. Genetic variability can be described using genealogical and molecular parameters characterizing variation in allelic frequencies over time and providing interesting information on differentiation that occurred after the foundation of a conservation program. Here we analyze the pedigree of the rare Xalda sheep breed (1851 individuals) and the polymorphism of 14 microsatellites in 239 Xalda individuals. Individuals were assigned to a base population (BP) or 4 different cohorts (from C1 to C4) according to their pedigree information. Genetic parameters were computed at a genealogical and molecular level, namely inbreeding (F), observed (H o) and expected (H e) heterozygosity, individual coancestry coefficients (f and f m), average relatedness (AR), mean molecular kinship (Mk), average number of allele per locus (A), effective number of ancestors (f a ), effective population size (N e and N emZ) and founder genome equivalents (N g and N gmZ). In general, the computed parameters increased with pedigree depth from BP to C4, especially for the genealogical information and molecular coancestry-based parameters (f m, Mk and N gmZ). However, H o and H e showed the highest values for C1 and the molecular heterozygote deficiency within population (F ISmZ) showed the lowest value for C1, thus indicating that loss of genetic variability occurs very soon after the implementation of conservation strategies. Although no genealogical or molecular parameters are sufficient by themselves for monitoring populations at the beginning of a conservation program, our data suggests that coancestry-based parameters may be better criteria than those of inbreeding or homozygosity because of the rapid and strong correlation established between f and f mZ. However, the obtaining of molecular information in well-established conservation programs could not be justified, at least in economic terms.
机译：保护稀有遗传资源需要对种群进行连续监测，以避免遗传变异性的损失。遗传变异性可以通过描述等位基因频率随时间变化的谱系和分子参数来描述，并提供有关在保存计划建立后发生的分化的有趣信息。在这里，我们分析了稀有的Xalda绵羊品种（1851个个体）的谱系和239个Xalda个体中14个微卫星的多态性。根据其谱系信息，将个体分配到一个基本人群（BP）或4个不同的队列（从C1到C4）。在族谱和分子水平上计算遗传参数，即近交（F），观察到（H o）和预期（H e）杂合性，个体遗传系数（f和fm），平均亲缘关系（AR），平均分子亲缘关系（Mk ），每个基因座的平均等位基因数量（A），祖先的有效数量（fa），有效种群数量（N e和N emZ）以及奠基者基因组当量（N g和N gmZ）。通常，计算的参数随谱系深度从BP到C4的增加而增加，特别是对于家谱信息和基于分子祖先的参数（f m，Mk和N gmZ）而言。然而，H o和H e显示出C1的最高值，而群体内的分子杂合子缺乏症（F ISmZ）显示出C1的最低值，因此表明在实施保护策略后不久就发生了遗传变异。尽管在保护程序开始时，没有任何家谱或分子参数足以单独监测种群，但我们的数据表明，基于祖先的参数可能比近交或纯合性更好，因为f和f之间建立了快速而强烈的相关性。 f mZ。但是，至少从经济角度来讲，无法通过完善的保护计划获得分子信息。

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