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首页> 外文期刊>Cellular immunology >Dendritic cell maturation occurs through the inhibition of GSK-3beta.
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Dendritic cell maturation occurs through the inhibition of GSK-3beta.

机译：树突状细胞的成熟通过抑制GSK-3beta而发生。

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Dendritic cell (DC) maturation results in changes in antigen processing and presentation, governing the fate of adaptive immunity. Understanding the intracellular signaling pathways governing DC maturation is therefore critical. In this study, we observed that the kinase, GSK-3beta, is present in its active form in resting immature DCs isolated from the spleen and bone marrow of mice. Induction of DC maturation using GM-CSF, IL-4 and TNF-alpha resulted in GSK-3beta inhibition, as reflected by increased phosphorylation of Serine 9 on the kinase, and concomitant stabilization of its substrate, beta-catenin. Treatment of immature DCs with a GSK-3beta inhibitor increased cell surface expression of CD80, CD86 and CD40 on DCs, enhancing their ability to present antigen and activating IL-2 secretion by T cells. GSK-3beta inhibition also parallels dendritic cell maturation in vivo. Our results show that GSK-3beta signaling controls DC maturation and suggest that this kinase could be manipulated to modulate adaptive immunity.
机译：树突状细胞（DC）的成熟导致抗原加工和呈递的改变，从而控制了适应性免疫的命运。因此，了解控制DC成熟的细胞内信号传导途径至关重要。在这项研究中，我们观察到GSK-3beta激酶以其活性形式存在于从小鼠脾脏和骨髓中分离出来的静止的未成熟DC中。使用GM-CSF，IL-4和TNF-α诱导DC成熟会导致GSK-3beta抑制，这反映在激酶上丝氨酸9的磷酸化增加，以及其底物β-连环蛋白的稳定作用。用GSK-3beta抑制剂处理未成熟的DC可增加DC上CD80，CD86和CD40的细胞表面表达，增强其呈递抗原的能力并激活T细胞分泌IL-2。 GSK-3beta抑制也平行于体内树突状细胞成熟。我们的结果表明，GSK-3beta信号控制了DC的成熟，并表明该激酶可以被操纵来调节适应性免疫。

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