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首页> 外文期刊>Cellular immunology >The immune enhancement of propolis adjuvant on inactivated porcine parvovirus vaccine in guinea pig.
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The immune enhancement of propolis adjuvant on inactivated porcine parvovirus vaccine in guinea pig.

机译：蜂胶佐剂对豚鼠灭活猪细小病毒疫苗的免疫增强作用。

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Two experiments were carried out. In immune response test, the immune enhancement of propolis, oilemulsion and aluminium salt were compared in guinea pig vaccinated with inactivated porcine parvovirus (PPV) vaccine. The result showed that three adjuvants could enhance antibody titer, T lymphocyte proliferation, IL-2 and IL-4 secretion of splenic lymphocyte. The action of propolis was similar to that of oilemulsion and superior to that of aluminium salt, especially in early period of vaccination propolis could accelerate antibody production. In immune protection test, the effects of three adjuvants on PPV infection were compared in guinea pig vaccinated with PPV vaccine then challenged with PPV. The result showed that propolis and oilemulsion could enhance the antibody titer, IL-2 and IL-4 content in serum and decrease the PPV content in blood and viscera. In the effect of improving cellular immune response, the propolis was the best. These results indicated that propolis possessed better immune enhancement and would be exploited into a effective adjuvant of inactivated vaccine.
机译：进行了两个实验。在免疫反应测试中，比较了接种灭活猪细小病毒（PPV）疫苗的豚鼠中蜂胶，油乳剂和铝盐的免疫增强作用。结果表明，三种佐剂均可提高脾脏淋巴细胞的抗体滴度，T淋巴细胞增殖，IL-2和IL-4分泌。蜂胶的作用类似于油乳剂，并且优于铝盐，尤其是在疫苗接种的早期蜂胶可以加速抗体的产生。在免疫保护试验中，比较了接种PPV疫苗然后再接种PPV的豚鼠中三种佐剂对PPV感染的影响。结果表明蜂胶和油乳剂可提高血清中抗体滴度，IL-2和IL-4含量，降低血液和内脏中PPV含量。在改善细胞免疫反应的效果中，蜂胶是最好的。这些结果表明蜂胶具有更好的免疫增强作用，将被用作灭活疫苗的有效佐剂。

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