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首页> 外文期刊>Cellular immunology >Lewis X oligosaccharides-heparanase complex targeting to DCs enhance antitumor response in mice.
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Lewis X oligosaccharides-heparanase complex targeting to DCs enhance antitumor response in mice.

机译：靶向DC的Lewis X寡糖-乙酰肝素酶复合物可增强小鼠的抗肿瘤反应。

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Heparanase has been proved as an promising tumor antigen for the therapeutical target. However, the antigen alone cannot fully elicit the immune response in vivo. In this study, Lewis X oligosaccharides-heparanase complex was prepared, which can target to the dendritic cells (DCs) via dendritic cell-specific intercellular-adhesion-molecule-grabbing non-integrin (DC-SIGN). In addition, the DCs were loaded with the complex, and then were utilized to immunize mice to detect the immune response. Our data demonstrated that the modified DCs could enhance the specific IFN-gamma production and cytotoxic T cell response. Furthermore, the modified DCs could also significantly suppress the established tumor growth and prolong the life span of tumor-bearing mice. Therefore, the Lewis X oligosaccharides-heparanase complex might be regarded as an ideal vaccine, and represent a novel way for the therapeutical strategy of tumor.
机译：乙酰肝素酶已被证明是用于治疗靶标的有希望的肿瘤抗原。然而，仅抗原不能完全引起体内免疫反应。在这项研究中，制备了Lewis X寡糖-乙酰肝素酶复合物，该复合物可以通过树突状细胞特异性细胞间粘附分子捕获非整联蛋白（DC-SIGN）靶向树突状细胞（DCs）。此外，DC上装有复合物，然后用于免疫小鼠以检测免疫反应。我们的数据表明，修饰的DC可以增强特定的IFN-γ产生和细胞毒性T细胞反应。此外，修饰的DC还可显着抑制已建立的肿瘤生长并延长荷瘤小鼠的寿命。因此，Lewis X寡糖-乙酰肝素酶复合物可能被认为是理想的疫苗，代表了一种新的肿瘤治疗策略。

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