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首页> 外文期刊>Cellular immunology >Anti-Pim-1 mAb inhibits activation and proliferation of T lymphocytes and prolongs mouse skin allograft survival.
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Anti-Pim-1 mAb inhibits activation and proliferation of T lymphocytes and prolongs mouse skin allograft survival.

机译：抗Pim-1 mAb抑制T淋巴细胞的活化和增殖，并延长小鼠皮肤同种异体移植物的存活时间。

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摘要

Pim-1 is an important signaling molecule mediating cell proliferation and survival. Our previous study identified a Pim-1 specific monoclonal antibody, P9, with significant inhibitory effect on cell proliferation. Herein, we report that P9 inhibited the activation and proliferation of PHA-stimulated human PBMC and induced them to undergo apoptosis. In contrast, P9 showed little effect on freshly isolated human blood T lymphocytes which poorly expressed Pim-1. P9 also detected an up-regulation of Pim-1 in mouse lymphocytes after mitogen stimulation, and showed similar selective inhibition on stimulated cells as observed with hPBMC. Furthermore, P9 inhibited the in vitro mixed lymphocyte reaction and P9 treatment significantly prolonged the survival of mouse skin allografts (P<0.001). It is concluded that Pim-1 expression correlates with lymphocyte proliferation and activation. P9 functions as a Pim-1 antagonist and is potential for immunosuppressive therapy.
机译：Pim-1是介导细胞增殖和存活的重要信号分子。我们先前的研究确定了Pim-1特异性单克隆抗体P9，对细胞增殖具有明显的抑制作用。在本文中，我们报道了P9抑制PHA刺激的人PBMC的激活和增殖，并诱导它们进行凋亡。相反，P9对新鲜分离的人T淋巴细胞表达几乎没有影响，后者的Pim-1表达差。在有丝分裂原刺激后，P9还检测到小鼠淋巴细胞中Pim-1的上调，并且与hPBMC相比，对刺激的细胞表现出类似的选择性抑制作用。此外，P9抑制了体外混合淋巴细胞反应，P9处理显着延长了小鼠皮肤同种异体移植物的存活时间（P <0.001）。结论是Pim-1表达与淋巴细胞增殖和活化有关。 P9用作Pim-1拮抗剂，可能具有免疫抑制作用。

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