Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection.

Delogu G; Sali M; Rocca S; Quintiliani G; Santucci MB; Greco E; Cabibbo A; Mariani F; Colizzi V; Fadda G; Fraziano M

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Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection.

机译：溶血磷脂酸可增强体内原发性结核分枝杆菌感染过程中的抗分枝杆菌反应。

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Lysophospholipids may play an important protective role during primary infection of Mycobacterium tuberculosis (MTB) by enhancing innate antimycobacterial immune response of both macrophages and alveolar epithelial cells. Here, we show that treatment with lysophosphatidic acid (LPA) of mice aerogenically infected with MTB immediately after infection results in a significant early reduction of pulmonary CFUs and of histopathological damage in comparison with control mice. In contrast, treatment of acute disease does not result in any improvement of both microbiological and histopathological parameters. Altogether, these results show that LPA treatment can exert protective effect if administrated during primary infection, only.

机译：溶血磷脂可能通过增强巨噬细胞和肺泡上皮细胞的固有抗分枝杆菌免疫应答而在结核分枝杆菌（MTB）的初次感染中发挥重要的保护作用。在这里，我们显示，与对照小鼠相比，感染后立即用MTB气生性感染MTB的小鼠用溶血磷脂酸（LPA）处理可导致肺CFU的早期显着减少和组织病理学损害。相反，急性疾病的治疗不会导致微生物学和组织病理学参数的任何改善。总而言之，这些结果表明，仅在原发感染期间施用LPA治疗才能发挥保护作用。

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《Cellular immunology》 |2011年第1期|共4页
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Delogu G; Sali M; Rocca S; Quintiliani G; Santucci MB; Greco E; Cabibbo A; Mariani F; Colizzi V; Fadda G; Fraziano M;
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中图分类细胞生物学;
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1. Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection. [J] . Delogu G, Sali M, Rocca S, Cellular immunology . 2011,第1期

机译：溶血磷脂酸可增强体内原发性结核分枝杆菌感染过程中的抗分枝杆菌反应。
2. Lysophosphatidic acid enhances antimycobacterial activity both in vitro and ex vivo. [J] . Garg SK, Valente E, Greco E, Clinical immunology: The official journal of the Clinical Immunology Society . 2006,第1期

机译：溶血磷脂酸增强了体外和离体的抗分枝杆菌活性。
3. Lactic acid bacteria enhance autophagic ability of mononuclear phagocytes by increasing Th1 autophagy-promoting cytokine (IFN-gamma) and nitric oxide (NO) levels and reducing Th2 autophagy-restraining cytokines (IL-4 and IL-13) in response to Mycobacterium tuberculosis antigen. [J] . Ghadimi D, de Vrese M, Heller KJ, International immunopharmacology . 2010,第6期

机译：乳酸菌通过响应结核分枝杆菌抗原增加Th1自噬促进细胞因子（IFN-γ）和一氧化氮（NO）的水平并降低Th2自噬抑制细胞因子（IL-4和IL-13）来增强单核吞噬细胞的自噬能力。。
4. Analysis Of Proteome Response of Mycobacterium smegmatis and Mycobacterium tuberculosis in an Integrated Stress Environment [C] . Prahlad K. Rao, Qingbo Li American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：分枝杆菌和结核分枝杆菌蛋白质组反应分析综合应力环境
5. The innate immune response to Mycobacterium tuberculosis infection. [D] . Manzanillo, Paolo Solano. 2013

机译：对结核分枝杆菌感染的先天免疫反应。
6. Antimycobacterial Agent Based on mRNA Encoding Human β-Defensin 2 Enables Primary Macrophages To Restrict Growth of Mycobacterium tuberculosis [O] . Kevin O. Kisich, Leonid Heifets, Michael Higgins, 2001

机译：基于编码人β-防御素2的mRNA的抗分枝杆菌药可使原代巨噬细胞限制结核分枝杆菌的生长
7. Enhanced immune response and protective effects of nano-chitosan-based DNA vaccine encoding T cell epitopes of Esat-6 and FL against Mycobacterium tuberculosis infection. [O] . Ganzhu Feng, Qingtao Jiang, Mei Xia, 2013

机译：增强的免疫反应和编码Esat-6和FL的T细胞表位的纳米壳聚糖基DNa疫苗对结核分枝杆菌感染的保护作用。
8. Real-Time Measurement of Host Bioenergetics During Mycobacterium Tuberculosis Infection. [R] . Steyn, A. J. 2015

机译：结核分枝杆菌感染过程中宿主生物能量的实时测量。

Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection.

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