• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular immunology >NK cells require type I IFN receptor for antiviral responses during genital HSV-2 infection.
【24h】

NK cells require type I IFN receptor for antiviral responses during genital HSV-2 infection.

机译：在生殖器HSV-2感染期间，NK细胞需要I型IFN受体才能产生抗病毒反应。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Type I interferon (IFN) signalling, NK cells and NK cell-derived IFN-gamma are critical in the early control of genital HSV-2 infection. We have recently reported that NK cells are the source of early IFN-gamma in the genital tract in response to HSV-2. However, the response of NK cells to genital HSV-2 infection is not well defined in the context of type I IFN signalling. Here we show that HSV-2 replication was significantly higher in mice deficient in the type I IFN receptor or NK cells compared to wild type controls. There was no detectable IFN-gamma production in the genital washes from IFN-alpha/betaR(-/-) mice or NK cell depleted mice in response to HSV-2 infection compared to control mice. Absence of the type I IFN receptor does not alter homing of NK cells to the genital mucosa. Moreover, the absence of IL-12 had no significant effect on NK cell-derived IFN-gamma. Surprisingly, IFN-alpha/betaR(-/-) mice had more IL-15 positive cells in the genital mucosa in response to HSV-2 infection compared to control mice. We then examined the expression of IL-15 receptors on NK cells. There was no significant differences in the levels of IL-15 receptor expression on NK cells from IFN-alpha/betaR(-/-) or control mice. Our data clearly suggest that type I IFN receptor signalling is essential for NK cell activation in response to genital HSV-2 infection, and propose that NK cell activation by IL-15 may involve type I IFNs.
机译：I型干扰素（IFN）信号传导，NK细胞和NK细胞衍生的IFN-γ对生殖器HSV-2感染的早期控制至关重要。我们最近报道，NK细胞是生殖道中对HSV-2应答的早期IFN-γ的来源。然而，在I型IFN信号传导的背景下，NK细胞对生殖器HSV-2感染的反应还没有很好地定义。在这里，我们显示与野生型对照相比，在缺乏I型IFN受体或NK细胞的小鼠中，HSV-2复制明显更高。与对照小鼠相比，在响应HSV-2感染的IFN-α/ betaR（-/-）小鼠或NK细胞耗竭的小鼠的生殖器清洗液中没有可检测到的IFN-γ产生。 I型IFN受体的缺失不会改变NK细胞向生殖器粘膜的归巢。此外，IL-12的缺乏对源自NK细胞的IFN-γ并无明显影响。令人惊讶的是，与HSV-2感染相比，IFN-α/ betaR（-/-）小鼠生殖器官粘膜中的IL-15阳性细胞多于对照小鼠。然后，我们检查了NK细胞上IL-15受体的表达。在来自IFN-α/ betaR（-/-）或对照小鼠的NK细胞上，IL-15受体表达水平没有显着差异。我们的数据清楚地表明，I型IFN受体信号传导对于生殖器HSV-2感染对NK细胞的激活至关重要，并提出IL-15对NK细胞的激活可能涉及I型IFN。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号