• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular immunology >Development of peritoneal macrophage along a dendritic cell lineage in response to uptake of oligomannose-coated liposomes.
【24h】

Development of peritoneal macrophage along a dendritic cell lineage in response to uptake of oligomannose-coated liposomes.

机译：响应于寡甘露糖涂层的脂质体的吸收，沿树突状细胞谱系发展腹膜巨噬细胞。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study, we investigate the potential of peritoneal macrophages to differentiate into dendritic cell (DCs) in response to preferential uptake of oligomannose-coated liposomes (OMLs). About 30% of peritoneal cells (PECs) preferentially took up OMLs that were administered into the peritoneal cavity. The OML-ingesting cells expressed CD11b and F4/80, but lacked CD11c expression, indicating that the OML-ingesting PECs with a CD11b(high)CD11c(-) phenotype are resident peritoneal macrophages. During in vitro cultivation, CD11c(+) cells arose among the PECs with ingested OMLs. CD11c(+) cells also developed among enriched peritoneal CD11b(high)CD11(-) cells from OML-treated mice, and the resulting CD11c(+) cells expressed co-stimulatory molecules and MHC class II. In addition, OML-ingesting CD11b(high)CD11c(+) cells were found in spleen after the enriched peritoneal macrophages with ingested OMLs were transplanted in the peritoneal cavity of mice. These results show that a fraction of peritoneal macrophages can differentiate into mature DCs following uptake of OMLs.
机译：在这项研究中，我们调查了响应寡糖甘露糖衣脂质体（OMLs）的优先摄取，腹膜巨噬细胞分化为树突状细胞（DCs）的潜力。约30％的腹膜细胞（PEC）优先吸收被施用至腹膜腔的OML。 OML摄取细胞表达CD11b和F4 / 80，但缺乏CD11c表达，表明具有CD11b（高）CD11c（-）表型的OML摄取PEC是常驻腹膜巨噬细胞。在体外培养过程中，在摄入OML的PEC中出现CD11c（+）细胞。 CD11c（+）细胞也在OML处理的小鼠的腹膜CD11b（高）CD11（-）细胞中发展，并且所得CD11c（+）细胞表达了共刺激分子和II类MHC。此外，在将富含摄入的OML的腹膜巨噬细胞移植到小鼠腹腔后，在脾脏中发现了富含OML的CD11b（高）CD11c（+）细胞。这些结果表明，一部分腹膜巨噬细胞在摄取OML后可以分化为成熟的DC。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号