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Clinicopathologic features and genotyping of patients with chronic HBV infection in the Upper Egypt.

机译：上埃及慢性HBV感染患者的临床病理特征和基因分型

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摘要

The aim of this study was to determine the clinicopathologic features and Hepatitis B virus genotypes in HBV-infected patients in the Upper Egypt. Eighty-three HBsAg-positive patients (28 carriers, 14 with chronic hepatitis, 32 with liver cirrhosis and 9 with hepatocellular carcinoma) were enrolled. Blood was collected and serum samples obtained were screened for Hepatitis markers genotyping was conducted for 6 HBV genotypes (A through F) using a method for genotyping HBV by primer specific polymerase chain reaction. Genotype D was the only genotype detected in different clinical forms of chronic HBV infection (carriers, chronic hepatitis, cirrhosis and hepatocellular carcinoma) and, in all patients who had elevated or normal alanine aminotransferase levels and in all ages. HBeAg was absent in 78 patients suggesting the presence of pre-core or core mutations. Positive correlation was found among serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), histological activity index and grade of hepatitis. This study provides the first indication about the clinicopathologic features of HBV-infected patients in the Upper Egypt. It also reports the predominance of genotype D in this region.
机译：这项研究的目的是确定上埃及HBV感染患者的临床病理特征和乙型肝炎病毒基因型。招募了八十三例HBsAg阳性患者（28例携带者，14例慢性肝炎，32例肝硬化和9例肝细胞癌）。收集血液并筛选血清样品中的肝炎标志物。使用通过引物特异性聚合酶链反应对HBV进行基因分型的方法对6种HBV基因型（A至F）进行基因分型。 D基因型是在不同临床形式的慢性HBV感染（携带者，慢性肝炎，肝硬化和肝细胞癌）中以及所有年龄和年龄中丙氨酸转氨酶水平升高或正常的所有患者中唯一检测到的基因型。 78名患者中没有HBeAg，提示存在核心前或核心突变。血清天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT），组织活性指数和肝炎等级之间呈正相关。这项研究为上埃及地区HBV感染患者的临床病理特征提供了第一个指征。它还报告了该地区基因型D的优势。

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