• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular immunology >Modulation of MOG 37-50-specific CD8(+) T cell activation and expansion by CD43
【24h】

Modulation of MOG 37-50-specific CD8(+) T cell activation and expansion by CD43

机译：通过CD43调节MOG 37-50特异性CD8（+）T细胞的活化和扩增

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Several recent reports have described an effector role for CD8(+) T cells during EAE. We have previously demonstrated reduced disease incidence and severity in CD43(-/-) mice following MOG immunization, and attributed this attenuation in disease progression to the effects of CD43 deficiency on CD4(+) T cells. Here, we extend those studies to examine the effects of the loss of CD43 on MOG-specific CD8(+) T cells. A reduced frequency of MOG-specific CD8(+) T cells following immunization was observed in CD43(-/-) mice relative to wild-type controls, as demonstrated by intracellular cytokine and MHC tetramer staining. In addition, adoptive transfer of CD8(+) MOG 35-55-primed LN cells from CD43(-/-) mice resulted in significantly attenuated EAE induction as compared to recipients of wild-type CD8(+) MOG-primed cells. Analysis of intracellular signaling intermediates revealed a deficiency in the ability of MOG-specific CD8(+) T cells to phosphorylate ERK in response to antigen. These results characterize an important role for CD43 during the activation and expansion of autoreactive MOG-specific CD8(+) T cells. (c) 2006 Elsevier Inc. All rights reserved.
机译：最近的几篇报道描述了EAE期间CD8（+）T细胞的效应子作用。我们先前已经证明，MOG免疫后CD43（-/-）小鼠的疾病发病率和严重性降低，并且疾病进展的这种减弱归因于CD43缺乏对CD4（+）T细胞的影响。在这里，我们将那些研究扩展到检查CD43丢失对MOG特异性CD8（+）T细胞的影响。相对于野生型对照，在CD43（-/-）小鼠中观察到免疫后MOG特异性CD8（+）T细胞的频率降低，如细胞内细胞因子和MHC四聚体染色所证实。此外，与野生型CD8（+）MOG引发的细胞的受体相比，CD43（-/-）小鼠的CD8（+）MOG 35-55引发的LN细胞的过继转移导致EAE诱导显着减弱。细胞内信号转导中间体的分析表明，MOG特异性CD8（+）T细胞响应抗原而磷酸化ERK的能力不足。这些结果表征了CD43在活化和扩增自身反应性MOG特异性CD8（+）T细胞过程中的重要作用。 （c）2006 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号