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首页> 外文期刊>Radiology >Metastatic gastrinomas: localization with selective arterial injection of secretin.
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Metastatic gastrinomas: localization with selective arterial injection of secretin.

机译：转移性胃泌素瘤：局部选择性注射促胰液素。

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摘要

PURPOSE: To evaluate localization of hepatic metastases with the intraarterial secretin injection test in Zollinger-Ellison syndrome (ZES). MATERIALS AND METHODS: Results in 74 patients with ZES (aged 15-70 years) were retrospectively studied. All patients had undergone computed tomography (CT), magnetic resonance (MR) imaging, ultrasound, abdominal angiography, and an intraarterial secretin test, in which venous blood is sampled periodically after injection of secretin. RESULTS: Twenty-two patients had liver metastases. An increase in venous gastrin concentration of at least 25% at 20 seconds or 50% at 30 seconds after injection indicated a positive result. Results were positive in 41% of patients with and 2% without liver metastases (P < .0001). Sensitivity of the intraarterial secretin test was 41%; of CT and ultrasound, 64%; and of MR imaging and angiography, 77%. Intraarterial secretin test results assisted in clinical management in 22% of patients. CONCLUSION: With the criteria developed, the intraarterial secretin test had high specificity but low sensitivity. It should be used when imaging results are unclear.
机译：目的：通过Zollinger-Ellison综合征（ZES）的动脉内分泌素注射试验评估肝转移的定位。材料与方法：回顾性研究74例ZES患者（年龄15-70岁）的结果。所有患者均接受了计算机断层扫描（CT），磁共振（MR）成像，超声，腹部血管造影和动脉内分泌素测试，其中在注射分泌素后定期取样静脉血。结果：22例患者发生肝转移。注射后20秒时静脉胃泌素浓度增加至少25％，或30秒时静脉胃泌素浓度增加至少50％，表明呈阳性结果。 41％有肝转移的患者和2％无肝转移的患者为阳性（P <.0001）。动脉内分泌素测试的敏感性为41％; CT和超声检查占64％; MR成像和血管造影占77％。动脉内分泌素测试结果有助于22％的患者进行临床管理。结论：随着标准的制定，动脉内分泌素检测具有较高的特异性，但敏感性较低。当成像结果不清楚时，应使用它。

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