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首页> 外文期刊>Cell and Tissue Research >Distribution of carnosine-like peptides in the nervous system of developing and adult zebrafish (Danio rerio) and embryonic effects of chronic carnosine exposure.
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Distribution of carnosine-like peptides in the nervous system of developing and adult zebrafish (Danio rerio) and embryonic effects of chronic carnosine exposure.

机译：肌肽样肽在发育中和成年斑马鱼（斑马鱼）的神经系统中的分布以及长期暴露于肌肽中的胚胎作用。

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Carnosine-like peptides (carnosine-LP) are a family of histidine derivatives that are present in the nervous system of various species and that exhibit antioxidant, anti-matrix-metalloproteinase, anti-excitotoxic, and free-radical scavenging properties. They are also neuroprotective in animal models of cerebral ischemia. Although the function of carnosine-LP is largely unknown, the hypothesis has been advanced that they play a role in the developing nervous system. Since the zebrafish is an excellent vertebrate model for studying development and disease, we have examined the distribution pattern of carnosine-LP in the adult and developing zebrafish. In the adult, immunoreactivity for carnosine-LP is specifically concentrated in sensory neurons and non-sensory cells of the olfactory epithelium, the olfactory nerve, and the olfactory bulb. Robust staining has also been observed in the retinal outer nuclear layer and the corneal epithelium. Developmental studies have revealed immunostaining for carnosine-LP as early as 18 h, 24 h, and 7 days post-fertilization in, respectively, the olfactory, corneal, and retinal primordia. These data suggest that carnosine-LP are involved in olfactory and visual function. We have also investigated the effects of chronic (7 days) exposure to carnosine on embryonic development and show that 0.01 microM to 10 mM concentrations of carnosine do not elicit significant deleterious effects. Conversely, treatment with 100 mM carnosine results in developmental delay and compromised larval survival. These results indicate that, at lower concentrations, exogenously administered carnosine can be used to explore the role of carnosine in development and developmental disorders of the nervous system.
机译：肌肽样肽（carnosine-LP）是组氨酸衍生物的家族，存在于各种物种的神经系统中，并表现出抗氧化剂，抗基质金属蛋白酶，抗兴奋毒性和自由基清除特性。它们在脑缺血的动物模型中也具有神经保护作用。尽管肌肽-LP的功能尚不清楚，但已经提出了假说，即肌肽在神经系统的发育中起作用。由于斑马鱼是研究发育和疾病的出色脊椎动物模型，因此我们研究了肌肽在成人和发育中斑马鱼中的分布模式。在成年人中，肌肽-LP的免疫反应性特别集中在嗅觉上皮，嗅觉神经和嗅球的感觉神经元和非感觉细胞中。在视网膜外核层和角膜上皮中也观察到了牢固的染色。发育研究表明，分别在嗅觉，角膜和视网膜原基受精后的18 h，24 h和7天，对肌肽LP进行了免疫染色。这些数据表明肌肽-LP参与嗅觉和视觉功能。我们还研究了肌肽长期（7天）暴露对胚胎发育的影响，并显示0.01μM至10 mM的肌肽浓度不会引起明显的有害作用。相反，用100 mM肌肽治疗会导致发育延迟和幼虫存活期受损。这些结果表明，在较低浓度下，外源性肌肽可用于探索肌肽在神经系统发育和发育障碍中的作用。

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