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首页> 外文期刊>Radiology >Inflammation within carotid atherosclerotic plaque: assessment with late-phase contrast-enhanced US.
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Inflammation within carotid atherosclerotic plaque: assessment with late-phase contrast-enhanced US.

机译：颈动脉粥样硬化斑块内的炎症：晚期对比增强超声评估。

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PURPOSE: To determine if the number of nontargeted microbubbles retained in human carotid plaque is sufficient to be detected with ultrasonography (US). MATERIALS AND METHODS: The study protocol was approved by the local research ethics committee. Informed consent was obtained. A total of 37 subjects with carotid atherosclerosis (mean age, 69.9 years; age range, 49-86 years), of whom 27 (73%) were men (mean age, 69.7 years; age range, 58-86 years) and 10 (27%) were women (mean age, 70.3 years; age range, 49-86 years), were studied between December 2008 and May 2009 with late-phase (LP) contrast material-enhanced US by using flash imaging with a nonlinear mode at an intermediate mechanical index of 0.34 6 minutes after bolus contrast agent injection. Plaques were defined as symptomatic if symptoms consistent with stroke, transient ischemic attack, or amaurosis fugax had occurred in the neurovascular territory of the plaque studied within 12 months prior to entry into the study. Plaques were defined as asymptomatic if no such events had ever occurred within the neurovascular territory. Raw linear data were used to quantify echogenicity of the plaque, which was normalized to lumen echogenicity. Gray-scale median score was also calculated. RESULTS: Of the 37 subjects, 16 (43%) had symptomatic plaques and 21 (57%) had asymptomatic plaques. All examinations yielded evaluable LP contrast-enhanced US data. Normalized LP plaque echogenicity was greater in the symptomatic group (0.39; 95% confidence interval: -0.11, 0.89) than in the asymptomatic group (0.69; 95% confidence interval: -1.04, -0.34) (P = .0005). There was a moderate (rho = -0.44, P = .016) inverse correlation between normalized LP plaque echogenicity and gray-scale median score. CONCLUSION: By quantifying microbubble retention within the carotid plaque, LP contrast-enhanced US depicts clear differences between groups of subjects with plaque ipsilateral to symptoms and asymptomatic plaques. This technique has promise as a tissue-specific marker of inflammation and a potential role in the risk stratification of atherosclerotic carotid stenosis.
机译：目的：确定保留在人颈动脉斑块中的非靶向微泡的数量是否足以通过超声检查（US）进行检测。材料与方法：研究方案经当地研究伦理委员会批准。获得知情同意。共有37位颈动脉粥样硬化受试者（平均年龄69.9岁;年龄范围49-86岁），其中27位（73％）是男性（平均年龄69.7岁;年龄范围58-86岁）和10位（27％）是女性（平均年龄70.3岁;年龄范围49-86岁），于2008年12月至2009年5月之间使用非线性模式的闪光成像技术对晚期（LP）造影剂增强的美国进行了研究推注造影剂后6分钟的中间机械指数为0.34。如果在进入研究之前的12个月内，在所研究的斑块的神经血管区域中出现了与中风，短暂性脑缺血发作或黑桃病相符的症状，则将斑块定义为有症状的。如果在神经血管区域内从未发生过此类事件，则将斑块定义为无症状。原始线性数据用于量化斑块的回声，将其标准化为管腔回声。还计算了灰度中位数。结果：37名受试者中，有16名（43％）有症状斑块，有21名（57％）无症状斑块。所有检查均产生了可评估的LP对比增强的美国数据。有症状组的标准化LP斑回声性（0.39; 95％置信区间：-0.11，0.89）大于无症状组（0.69; 95％置信区间：-1.04，-0.34）（P = .0005）。在归一化的LP斑块回声性和灰度中位数之间存在中等程度的逆相关（rho = -0.44，P = .016）。结论：通过定量颈动脉斑块内的微气泡保留，LP对比增强的US描绘了与症状和无症状斑块同侧的斑块对象组之间的明显差异。该技术有望作为炎症的组织特异性标志物，并在动脉粥样硬化性颈动脉狭窄的危险分层中发挥潜在作用。

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