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Prostate cancer: relative effects of demographic, clinical, histologic, and MR imaging variables on the accuracy of staging.

机译：前列腺癌：人口统计学，临床，组织学和MR影像变量对分期准确性的相对影响。

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PURPOSE: To determine the effects on the accuracy of staging prostate gland cancer of diagnostic prediction rules based on demographic, clinical, histologic, and magnetic resonance (MR) image variables. MATERIALS AND METHODS: A total of 200 cases from four medical centers were evaluated by nine radiologists experienced in MR imaging. The accuracies of the four diagnostic variables (age, prostate specific antigen level, Gleason tumor grade, and MR imaging findings) were measured, both singly and combined in a particular sequence, by calculating the area index of the receiver operating characteristic curve. RESULTS: The accuracy of staging with single variables (age, 0.58; prostate specific antigen level, 0.74; Gleason grade 0.73, MR image findings, 0.74) increased as the variables were optimally merged. The first two variables combined to yield an accuracy of 0.74; the first three combined to yield an accuracy of 0.81; and all four variables resulted in an accuracy of 0.86. In a clinically important subset of 69 cases for which antigen level and Gleason grade together were inconclusive for the purposes of staging, the addition of MR imaging findings resulted in an increase in accuracy from 0.55 to 0.73. CONCLUSION: Optimal merging of diagnostic test results yields an improvement in the accuracy of prostate cancer staging.
机译：目的：根据人口统计学，临床，组织学和磁共振（MR）图像变量，确定诊断预测规则对分期前列腺癌准确性的影响。材料与方法：由九个具有MR成像经验的放射科医生对来自四个医疗中心的200例病例进行了评估。通过计算接收器工作特征曲线的面积指数，分别测量并组合了四个诊断变量（年龄，前列腺特异抗原水平，格里森肿瘤等级和MR影像学发现）的准确性。结果：随着变量的最佳合并，单一变量（年龄，0.58;前列腺特异性抗原水平，0.74;格里森等级0.73，MR影像学发现，0.74）的分期准确性提高了。前两个变量的总和为0.74。前三者的总和为0.81;而所有四个变量的准确度均为0.86。在69例临床上重要的临床子集中，对于分期而言，抗原水平和格里森分级并非决定性因素，MR影像学发现的增加将准确性从0.55提高到0.73。结论：诊断测试结果的最佳合并可提高前列腺癌分期的准确性。

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