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首页> 外文期刊>Cell and Tissue Research >The developmental roles of the extracellular matrix: beyond structure to regulation.
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The developmental roles of the extracellular matrix: beyond structure to regulation.

机译：细胞外基质的发展作用：从结构到调控。

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摘要

Cells in multicellular organisms are surrounded by a complex three-dimensional macromolecular extracellular matrix (ECM). This matrix, traditionally thought to serve a structural function providing support and strength to cells within tissues, is increasingly being recognized as having pleiotropic effects in development and growth. Elucidation of the role that the ECM plays in developmental processes has been significantly advanced by studying the phenotypic and developmental consequences of specific genetic alterations of ECM components in the mouse. These studies have revealed the enormous contribution of the ECM to the regulation of key processes in morphogenesis and organogenesis, such as cell adhesion, proliferation, specification, migration, survival, and differentiation. The ECM interacts with signaling molecules and morphogens thereby modulating their activities. This review considers these advances in our understanding of the function of ECM proteins during development, extending beyond their structural capacity, to embrace their new roles in intercellular signaling.
机译：多细胞生物中的细胞被复杂的三维大分子细胞外基质（ECM）包围。传统上认为这种基质具有为组织内的细胞提供支持和强度的结构功能，越来越多地被认为在发育和生长中具有多效作用。通过研究小鼠中ECM成分的特定基因改变的表型和发育后果，对ECM在发育过程中所起的作用的阐明已得到显着发展。这些研究表明，ECM对形态发生和器官发生的关键过程的调控有巨大贡献，例如细胞粘附，增殖，特异性，迁移，存活和分化。 ECM与信号分子和形态发生子相互作用，从而调节其活性。这篇综述考虑了我们对ECM蛋白在发育过程中功能的理解方面的这些进展，这些进展超出了其结构能力，从而涵盖了它们在细胞间信号转导中的新作用。

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