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首页> 外文期刊>Cell and Tissue Research >Pathogenic antibody recognition of cartilage.
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Pathogenic antibody recognition of cartilage.

机译：软骨的致病性抗体识别。

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Antibodies against cartilage proteins are highly prevalent in the sera and synovial fluids of rheumatoid arthritis (RA) patients and also precede disease induction in various spontaneous and induced animal models of arthritis. These antibodies play an important role in the induction and perpetuation of the clinical disease. Antibodies binding to cartilage protein(s), especially the major articular cartilage protein, collagen type II (CII) can induce, in naive mice, an acute form of arthritis that can substantially destroy the cartilage and bone architecture. More importantly, these anti-CII antibodies can also directly cause the destruction of the target tissue preceding and independently of disease development and in the absence of any other pathogenic inflammatory factors or the action of immune cells. Alternatively, antibodies to citrullinated protein antigens and rheumatoid factor are well-validated prognostic and diagnostic markers of severe erosive RA, although their arthritogenic potential is questioned. Recently, we have found that the monoclonal antibodies to citrulline-modified cartilage protein can bind cartilage and synovial tissue and mediate arthritis in mice. Similarly, one of the pathogenic anti-CII monoclonal antibodies has rheumatoid-factor-like activity, suggesting a disease-inducing role for these commonly prevalent antibodies in RA patients. Interestingly, recent findings have also shown that the enzymatic cleavage or modification of pathogenic IgG antibodies protects the cartilage surface, thereby opening up new therapeutic possibilities for protecting the cartilage from inflammatory damage.
机译：抗软骨蛋白的抗体在类风湿关节炎（RA）患者的血清和滑液中高度流行，并且在各种自发性和诱发性关节炎动物模型中也早于疾病诱导。这些抗体在临床疾病的诱导和永存中起重要作用。与软骨蛋白，尤其是主要的关节软骨蛋白II型胶原（CII）结合的抗体可以在幼稚的小鼠中诱发一种急性关节炎，这种关节炎可以严重破坏软骨和骨骼的结构。更重要的是，在没有任何其他病原性炎性因子或免疫细胞作用的情况下，这些抗CII抗体还可以在疾病发展之前并且与疾病发展无关地直接引起靶组织的破坏。备选地，尽管人们质疑其致关节炎的潜力，但针对瓜氨酸化蛋白抗原和类风湿因子的抗体是严重侵蚀性RA的有效预后和诊断标志物。最近，我们发现瓜氨酸修饰的软骨蛋白的单克隆抗体可以结合软骨和滑膜组织并介导小鼠的关节炎。类似地，一种病原性抗CII单克隆抗体具有类风湿因子样活性，提示这些常见的抗体在RA患者中具有疾病诱导作用。有趣的是，最近的发现还表明，酶裂解或病原性IgG抗体的修饰可保护软骨表面，从而为保护软骨免遭炎症性损害开辟了新的治疗可能性。

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