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首页> 外文期刊>Recent patents on anti-cancer drug discovery >Light deficiency confers breast cancer risk by endocrine disorders.
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Light deficiency confers breast cancer risk by endocrine disorders.

机译：光照不足会因内分泌失调而增加患乳腺癌的风险。

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摘要

North-America and northern European countries exhibit the highest incidence rate of breast cancer, whereas women in southern regions are relatively protected. Immigrants from low cancer incidence regions to high-incidence areas might exhibit similarly higher or excessive cancer risk as compared with the inhabitants of their adoptive country. Additional cancer risk may be conferred by incongruence between their biological characteristics and foreign environment. Many studies established the racial/ethnic disparities in the risk and nature of female breast cancer in United States between African-American and Caucasian women. Mammary tumors in black women are diagnosed at earlier age, and are associated with higher rate of mortality as compared with cancers of white cases. Results of studies on these ethnic/racial differences in breast cancer incidence suggest that excessive pigmentation of dark skinned women results in a relative light-deficiency. Poor light exposure may explain the deleterious metabolic and hormonal alterations; such as insulin resistance, deficiencies of estrogen, thyroxin and vitamin-D conferring excessive cancer risk. The more northern the location of an adoptive country the higher the cancer risk for dark skinned immigrants. Recognition of the deleterious systemic effects of darkness and excessive melatonin synthesis enables cancer protection treatment for people living in light-deficient environment. Recent patents provide new methods for the prevention of hormonal and metabolic abnormities.
机译：北美和北欧国家的乳腺癌发病率最高，而南部地区的妇女则受到相对保护。与收养国家的居民相比，从低癌症发病率地区到高发病率地区的移民可能表现出同样更高或更高的癌症风险。由于其生物学特性和外来环境不一致，可能会增加癌症风险。许多研究确定了美国黑人和白人妇女在女性乳腺癌风险和性质方面的种族/种族差异。黑人女性的乳腺肿瘤被诊断为较早年龄，与白人女性相比，其死亡率更高。这些关于乳腺癌发病率的种族/种族差异的研究结果表明，深色皮肤女性过多的色素沉着导致相对的光缺乏。不良的光照可能解释了有害的代谢和激素变化。例如胰岛素抵抗，雌激素，甲状腺素和维生素D缺乏会导致癌症风险过高。收养国的地理位置越北部，深色皮肤移民的癌症风险就越高。认识到黑暗和褪黑激素合成的有害全身作用，可以为生活在光线不足的环境中的人们提供癌症保护治疗。最新的专利提供了预防荷尔蒙和代谢异常的新方法。

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