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Sex differences and estrogen regulation of miRNAs in lupus, a prototypical autoimmune disease

机译：狼疮（一种典型的自身免疫性疾病）中miRNA的性别差异和雌激素调节

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Unique dysregulated expression patterns of microRNAs (miRNAs) have been reported in many disease conditions including autoimmune diseases such as systemic lupus erythematosus (SLE). We have recently reported that miRNAs are differentially expressed not only between autoimmune and control mice, but also between male and female lupus-prone mice. This important observation is of potential clinical and experimental significance since females have higher incidence, earlier expression or severity of lupus when compared to their male counterparts. Further, estrogen administration to orchiectomized males accelerates the expression of lupus-related miRNAs and induces unique miRNA signature profile. Understanding the basis of altered miRNAs in autoimmune diseases offers a new paradigm to understand autoimmune diseases, including sex-differential susceptibility. In this review, we summarize miRNA biogenesis and function, and focus on miRNA dysregulation in SLE in the context of sexual bias. Furthermore, the effect of estrogen on epigenetic miRNA regulation in relation to SLE is highlighted. (C) 2015 Published by Elsevier Inc.
机译：在许多疾病中，包括自身免疫性疾病，例如系统性红斑狼疮（SLE），都已报道了microRNA（miRNA）独特的失调表达模式。最近，我们报道了miRNA不仅在自身免疫小鼠和对照小鼠之间表达，而且在雄性和雌性狼疮易感小鼠之间也有差异表达。这一重要发现具有潜在的临床和实验意义，因为与男性相比，女性狼疮的发病率更高，表达较早或严重。此外，将雌激素给予经睾丸切除的雄性可加速狼疮相关miRNA的表达并诱导独特的miRNA特征。了解自身免疫性疾病中改变的miRNA的基础为了解自身免疫性疾病（包括性别差异敏感性）提供了新的范例。在这篇综述中，我们总结了miRNA的生物发生和功能，并着重于性偏见背景下SLE中的miRNA失调。此外，强调了雌激素对与SLE有关的表观遗传miRNA调节的作用。 （C）2015年由Elsevier Inc.出版

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