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Evolution and function of the TCR Vgamma9 chain repertoire: It's good to be public

机译：TCR Vgamma9链库的演变和功能：公开是很好的

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Lymphocytes expressing a T cell receptor (TCR) composed of Vgamma9 and Vdelta2 chains represent a minor fraction of human thymocytes. Extrathymic selection throughout post-natal life causes the proportion of cells with a Vgamma9-JP rearrangement to increase and elevates the capacity for responding to non-peptidic phosphoantigens. Extrathymic selection is so powerful that phosphoantigen-reactive cells comprise about I in 40 circulating memory T cells in healthy adults and the subset expands rapidly upon infection or in response to malignancy. Skewing of the gamma delta TCR repertoire is accompanied by selection for public gamma chain sequences such that many unrelated individuals overlap extensive in their circulating repertoire. This type of selection implies the presence of a monomorphic antigen-presenting molecule that is an object of current research but remains incompletely defined. While selection on a monomorphic presenting molecule may seem unusual, similar mechanisms shape the alpha beta T cell repertoire including the extreme examples of NKT or mucosal-associated invariant T cells (MAIT) and the less dramatic amplification of public Vbeta chain rearrangements driven by individual MHC molecules and associated with resistance to viral pathogens. Selecting and amplifying public T cell receptors whether alpha beta or gamma delta, are important steps in developing an anticipatory TCR repertoire. Cell clones expressing public TCR can accelerate the kinetics of response to pathogens and impact host survival. (C) 2015 Elsevier Inc. All rights reserved.
机译：表达由Vgamma9和Vdelta2链组成的T细胞受体（TCR）的淋巴细胞仅占人类胸腺细胞的一小部分。整个出生后生命中的胸腺外选择导致具有Vgamma9-JP重排的细胞比例增加，并提高了对非肽磷酸抗原的反应能力。胸腺外选择如此强大，以至于在健康成年人中，磷酸抗原反应性细胞在40个循环记忆T细胞中约占I，而该亚群在感染或对恶性肿瘤的反应后迅速扩增。 γ-δTCR谱库的偏斜伴随着对公共γ链序列的选择，使得许多无关的个体在其循环库中广泛重叠。这种类型的选择意味着存在单态性抗原呈递分子，这是当前研究的对象，但仍未完全定义。尽管对单态呈递分子的选择似乎很不寻常，但类似的机制影响着αβT细胞的组成，包括NKT或与黏膜相关的不变T细胞（MAIT）的极端例子，以及由单个MHC驱动的公共Vbeta链重排的戏剧性扩增分子并与对病毒病原体的抗性有关。选择和扩增公共T细胞受体（无论是alpha beta还是gammaδ）是开发预期的TCR库的重要步骤。表达公共TCR的细胞克隆可以加速对病原体的反应动力学并影响宿主存活。 （C）2015 Elsevier Inc.保留所有权利。

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