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Immunoregulatory effects of sirolimus vs. tacrolimus treatment in kidney allograft recipients

机译：西罗莫司与他克莫司治疗对同种异体肾移植受者的免疫调节作用

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The difference in immunoregulatory effects between sirolimus and tacrolimus on kidney transplantation remains unclear. In this study, a total of 18 living-donor-related kidney transplant recipients received sirolimus (n = 8) or tacrolimus (n = 10) treatment. Kidney function, acute rejection, peripheral blood CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs), CD19(+)CD5(+)CD1d(+) regulatory B cells (Bregs), and panel reactivity antibody were analyzed after one and three years. Th1/2 cell polarization was also determined at one year. The proportion of Tregs in the recipients receiving tacrolimus significantly decreased to 3.69% and 2.49% at one and three years, respectively, compared to 6.59% in controls, whereas the proportion in the recipients receiving sirolimus remained at 6.67% and 5.66%, respectively. However, no differences in kidney function, acute rejection, proportion of Bregs, panel reactivity antibody, or the frequencies of Th1/2 cells were identified. In conclusion, unlike tacrolimus, sirolimus maintains the proportion of Tregs in kidney transplant recipients. (C) 2015 Elsevier Inc. All rights reserved.
机译：西罗莫司和他克莫司对肾脏移植的免疫调节作用的差异尚不清楚。在这项研究中，共有18位与活体供体相关的肾脏移植受者接受了西罗莫司（n = 8）或他克莫司（n = 10）的治疗。肾脏功能，急性排斥反应，外周血CD4（+）CD25（+）FOXP3（+）调节性T细胞（Tregs），CD19（+）CD5（+）CD1d（+）调节性B细胞（Bregs）和面板反应性抗体经过一年和三年的分析。 Th1 / 2细胞极化也确定在一年。在接受他克莫司治疗的受试者中，Tregs的比例在一年和三年时分别显着下降至3.69％和2.49％，而对照组为6.59％，而接受西罗莫司的受试者的比例分别保持在6.67％和5.66％。但是，没有发现肾脏功能，急性排斥反应，Bregs比例，面板反应性抗体或Th1 / 2细胞频率的差异。总之，与他克莫司不同，西罗莫司在肾脏移植受者中维持Treg的比例。 （C）2015 Elsevier Inc.保留所有权利。

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