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首页> 外文期刊>Cellular immunology >Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: a potential mechanism for intercellular HIV trafficking.
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Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: a potential mechanism for intercellular HIV trafficking.

机译：HIV巨噬细胞感染可诱导隧穿纳米管（TNT）：这是细胞间HIV贩运的潜在机制。

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摘要

Cell to cell communication is essential for the organization/coordination of multicellular systems and cellular development. Cellular communication is mediated by soluble factors, including growth factors, neurotransmitters, cytokines/chemokines, gap junctions, and the recently described tunneling nanotubes (TNT). TNT are long cytoplasmatic bridges that enable long range directed communication between cells. The proposed function for TNT is the cell-to-cell transfer of large cellular structures such as vesicles and organelles. We demonstrate that HIV-infection of human macrophages results in an increased number of TNT, and show HIV particles within these structures. We propose that HIV "highjacks" TNT communication to spread HIV through an intercellular route between communicated cells, contributing to the pathogenesis of AIDS.
机译：细胞间的通信对于多细胞系统的组织/协调和细胞发育至关重要。细胞通讯由可溶性因子介导，包括生长因子，神经递质，细胞因子/趋化因子，间隙连接和最近描述的隧穿纳米管（TNT）。 TNT是长的细胞质桥，可实现细胞之间的长距离定向通讯。 TNT的拟议功能是大型细胞结构（如小泡和细胞器）的细胞间转移。我们证明，人类巨噬细胞的HIV感染导致TNT数量增加，并在这些结构中显示HIV颗粒。我们建议艾滋病毒“劫持” TNT交流，以通过交流细胞之间的细胞间途径传播艾滋病毒，从而导致艾滋病的发病机理。

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