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首页> 外文期刊>Cellular microbiology >Candida albicans and Streptococcus salivarius modulate IL-6, IL-8, and TNF-alpha expression and secretion by engineered human oral mucosa cells
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Candida albicans and Streptococcus salivarius modulate IL-6, IL-8, and TNF-alpha expression and secretion by engineered human oral mucosa cells

机译：白色念珠菌和唾液链球菌可通过工程化的人类口腔粘膜细胞调节IL-6，IL-8和TNF-α的表达和分泌

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摘要

We investigated the involvement of oral epithelial cells via two cytokines (IL-6 and TNF-alpha) and one chemokine (IL-8) in local defences against live yeast (Candida albicans) and bacteria (Streptococcus salivarius) using an engineered human oral mucosa model. We report that the yeast changed from the blastospore to the hyphal form and induced significant tissue disorganization at later contact periods (24 and 48 h) compared to the bacteria. However, this effect did not reduce the viability or total number of epithelial cells. Gene activation analyses revealed that IL-6, IL-8 and TNF-alpha mRNA levels rose in tissues in contact with live C. albicans or S. salivarius. Gene activation was followed by an upregulation of protein secretion. IL-6 levels were higher after contact with C. albicans than with S. salivarius. IL-8 levels after contact with S. salivarius were higher than with C. albicans. Our study suggests that S. salivarius is more efficient at inducing proinflammatory mediator release than C. albicans. These results provide additional evidence for the contribution of oral epithelial cells to the inflammatory response against fungi and bacteria.
机译：我们使用工程化的人类口腔粘膜研究了通过两种细胞因子（IL-6和TNF-α）和一种趋化因子（IL-8）参与的口腔上皮细胞对活酵母（白色念珠菌）和细菌（唾液链球菌）的局部防御作用。模型。我们报道，与细菌相比，酵母在从接触孢子变为菌丝形式并在以后的接触时间（24和48 h）引起明显的组织紊乱。但是，这种作用不会降低上皮细胞的活力或总数。基因激活分析表明，与活的白色念珠菌或唾液链球菌接触的组织中，IL-6，IL-8和TNF-αmRNA的水平上升。基因激活后，蛋白分泌上调。与白色念珠菌接触后，IL-6水平高于唾液链球菌。与唾液链球菌接触后，IL-8水平高于白色念珠菌。我们的研究表明，唾液链球菌在诱导促炎性介质释放方面比白色念珠菌更有效。这些结果为口腔上皮细胞对真菌和细菌的炎症反应做出了贡献。

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