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首页> 外文期刊>Cell cycle >Neural potential of a stem cell population in the hair follicle.
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Neural potential of a stem cell population in the hair follicle.

机译：毛囊中干细胞种群的神经电势。

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The bulge region of the hair follicle serves as a repository for epithelial stem cells that can regenerate the follicle in each hair growth cycle and contribute to epidermis regeneration upon injury. Here we describe a population of multipotential stem cells in the hair follicle bulge region; these cells can be identified by fluorescence in transgenic nestin-GFP mice. The morphological features of these cells suggest that they maintain close associations with each other and with the surrounding niche. Upon explantation, these cells can give rise to neurosphere-like structures in vitro. When these cells are permitted to differentiate, they produce several cell types, including cells with neuronal, astrocytic, oligodendrocytic, smooth muscle, adipocytic, and other phenotypes. Furthermore, upon implantation into the developing nervous system of chick, these cells generate neuronal cells in vivo. We used transcriptional profiling to assess the relationship between these cells and embryonic and postnatal neural stem cells and to compare them with other stem cell populations of the bulge. Our results show that nestin-expressing cells in the bulge region of the hair follicle have stem cell-like properties, are multipotent, and can effectively generate cells of neural lineage in vitro and in vivo.
机译：毛囊的隆起区域充当上皮干细胞的储存库，上皮干细胞可以在每个毛发生长周期中再生毛囊，并在受伤时促进表皮再生。在这里，我们描述了毛囊隆起区域中的多能干细胞群体。这些细胞可以在转基因巢蛋白-GFP小鼠中通过荧光鉴定。这些细胞的形态学特征表明它们彼此之间以及与周围环境之间保持着紧密的联系。植入后，这些细胞可在体外产生神经球样结构。当允许这些细胞分化时，它们产生几种细胞类型，包括具有神经元，星形细胞，少突胶质细胞，平滑肌，脂肪细胞和其他表型的细胞。此外，在植入雏鸡发育中的神经系统后，这些细胞在体内产生神经元细胞。我们使用转录谱分析来评估这些细胞与胚胎和出生后神经干细胞之间的关系，并将其与凸起的其他干细胞群体进行比较。我们的结果表明，在毛囊隆起区域表达巢蛋白的细胞具有干细胞样特性，具有多能性，并且可以在体外和体内有效产生神经谱系细胞。

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