To die or not to die: neurons and p63.

Miller FD; Kaplan DR

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To die or not to die: neurons and p63.

机译：死亡或不死亡：神经元和p63。

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One of the fundamental questions in neurobiology is how mammalian neurons survive for an organism's lifetime in the face of normal ongoing "wear and tear" that, in the case of neurons in the peripheral nervous system, even includes physical damage. Elucidating the mechanisms that control neuronal survival is of importance not only for our understanding of normal development of neuronal circuitry, but also to devise treatments for pathological situations such as traumatic injury, or neurodegenerative conditions. In this review, we will cover the emerging evidence that p63 plays an essential role in regulating neuronal life and death decisions in the nervous system working in concert with its two other family members, p53 and p73.

机译：神经生物学的基本问题之一是面对正常的持续“磨损”，哺乳动物神经元如何在生物体的生命中生存，就周围神经系统中的神经元而言，甚至包括物理损伤。阐明控制神经元存活的机制不仅对于我们了解神经元回路的正常发育很重要，而且对于设计诸如创伤性损伤或神经退行性疾病等病理情况的治疗方法也很重要。在这篇综述中，我们将涵盖新出现的证据，证明p63与其他两个家族成员p53和p73协同工作，在调节神经系统中神经元的生死决定中起着至关重要的作用。

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《Cell cycle》 |2007年第3期|共6页
作者
Miller FD; Kaplan DR;
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正文语种 eng
中图分类细胞生物学;
关键词
neuronal circuitry; Review Publication Type; control; development aspects;

机译：神经元电路;综述[发表类型];控制;发展方面;

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To die or not to die: neurons and p63.

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