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首页> 外文期刊>Cellular immunology >N9 microglial cells polarized by LPS and IL4 show differential responses to secondary environmental stimuli
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N9 microglial cells polarized by LPS and IL4 show differential responses to secondary environmental stimuli

机译：LPS和IL4极化的N9小胶质细胞对次级环境刺激表现出不同的反应

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Microglia participates in the regulation of many inflammation-related pathological processes in the central nervous system, but how microglial activation is regulated has not been fully understood. Here, by using a microglial cell line, we show that microglia, like other macrophages, are activated by inflammatory stimuli in a polarized manner. The LPS-polarized M1 microglia appeared to be unable to respond to a secondary IL4 stimulation, while IL4-polarized M2 microglia could respond to secondary LPS stimulation. We also show that Notch signaling is involved in microglial polarization. When Notch signaling was blocked, the M1 polarization was suppressed, while the M2 polarization was promoted. Withdraw of the Notch signal inhibitor did not permit M2 N9 cells to re-polarize to M1 upon LPS stimulation, suggesting that the effects of Notch blockade on microglial polarization could be "memorized" by cells. These results suggest complicated mechanisms including epigenetic programs in the regulation of macrophage polarization.
机译：小胶质细胞参与中枢神经系统中许多与炎症相关的病理过程的调节，但是如何调节小胶质细胞的激活尚未完全了解。在这里，通过使用小胶质细胞系，我们显示小胶质细胞像其他巨噬细胞一样，以极化方式被炎性刺激激活。 LPS极化的M1小胶质细胞似乎无法对继发性IL4刺激作出反应，而IL4极化的M2小胶质细胞可以对继发性LPS刺激作出反应。我们还显示，Notch信号传导参与小胶质细胞极化。当Notch信号被阻断时，M1极化被抑制，而M2极化被促进。撤除Notch信号抑制剂后，LPS刺激后M2 N9细胞无法重新极化为M1，这表明细胞可以“记忆” Notch阻断对小胶质细胞极化的作用。这些结果表明在巨噬细胞极化调节中包括表观遗传程序的复杂机制。

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