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首页> 外文期刊>Cellular immunology >Deleterious versus protective autoimmunity in multiple sclerosis
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Deleterious versus protective autoimmunity in multiple sclerosis

机译：多发性硬化症的有害与保护性自身免疫

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Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disorder of central nervous system, in which myelin specific CD4(+) T cells have a central role in orchestrating pathological events involved in disease pathogenesis. There is compelling evidence that Th1, Th9 and Th17 cells, separately or in cooperation, could mediate deleterious autoimmune response in MS. However, the phenotype differences between Th cell subpopulations initially employed in MS pathogenesis are mainly reflected in the different patterns of inflammation introduction, which results in the development of characteristic pathological features (blood brain barrier disruption, demyelination and neurodegeneration), clinically presented with MS symptoms. Although, autoimmunity was traditionally seen as deleterious, some studies indicated that autoimmunity mediated by Th2 cells and T regulatory cells could be protective by nature. The concept of protective autoimmunity in MS pathogenesis is still poorly understood, but could be of great importance in better understanding of MS immunology and therefore, creating better therapeutic strategies. (C) 2015 Elsevier Inc. All rights reserved.
机译：多发性硬化症（MS）是中枢神经系统的一种慢性炎症和神经退行性疾病，其中髓鞘特异性CD4（+）T细胞在协调参与疾病发病机理的病理事件中具有中心作用。有令人信服的证据表明，Th1，Th9和Th17细胞可以单独或协同作用介导MS中有害的自身免疫反应。然而，最初用于MS发病机理的Th细胞亚群之间的表型差异主要反映在炎症引入的不同模式上，这导致特征性病理特征（血脑屏障破坏，脱髓鞘和神经变性）的发展，临床上表现为MS症状。尽管传统上认为自身免疫是有害的，但一些研究表明，Th2细胞和T调节细胞介导的自身免疫可能具有保护作用。在MS发病机制中保护性自身免疫的概念仍知之甚少，但在更好地了解MS免疫学并因此建立更好的治疗策略中可能具有重要意义。 （C）2015 Elsevier Inc.保留所有权利。

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