BID as a double agent in cell life and death.

Gross A

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BID as a double agent in cell life and death.

机译：BID是细胞生与死的双重作用。

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DNA damage leads to the activation of ATM and ATR, which in turn either cause cell cycle arrest and DNA repair or apoptosis. We have demonstrated that DNA damage leads to ATM-mediated BID phosphorylation, and that this phosphorylation regulates a novel, pro-survival function of BID important for S phase arrest. Thus, BID, a member from the core apoptotic regulatory machinery (BCL-2 family) receives direct inputs from a key regulator of the cell cycle arrest/DNA repair machinery (ATM), and therefore is an excellent candidate to coordinate genotoxic stress responses and apoptotic cell death.

机译：DNA损伤导致ATM和ATR激活，进而引起细胞周期停滞和DNA修复或凋亡。我们已经证明DNA损伤导致ATM介导的BID磷酸化，并且这种磷酸化调节BID对S期停滞重要的新型生存功能。因此，BID是核心细胞凋亡调控机制（BCL-2家族）的成员，它从细胞周期阻滞/ DNA修复机制（ATM）的关键调控子接受直接输入，因此是协调遗传毒性应激反应和凋亡细胞死亡。

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《Cell cycle》 |2006年第6期|共3页
作者
Gross A;
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正文语种 eng
中图分类细胞生物学;
关键词
Apoptosis; BH3 Interacting Domain Death Agonist Protein; Cell Cycle Proteins; 脱噬作用; 细胞周期蛋白质类; DNA结合蛋白质类; 蛋白质丝氨酸苏氨酸激酶;

机译：Apoptosis;BH3 Interacting Domain Death Agonist Protein;Cell Cycle Proteins;脱噬作用;细胞周期蛋白质类;DNA结合蛋白质类;蛋白质丝氨酸苏氨酸激酶;

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专利

1. BID as a double agent in cell life and death. [J] . Gross A Cell cycle . 2006,第6期

机译：BID是细胞生与死的双重作用。
2. The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non small cell lung carcinoma cells to DNA double-strand break induced cell death. [J] . Polischouk AG, Holgersson A, Zong D, Molecular cancer therapeutics . 2007,第8期

机译：抗精神病药三氟拉嗪抑制DNA修复并使非小细胞肺癌细胞对DNA双链断裂诱导的细胞死亡敏感。
3. Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death. [J] . Dumontet C, Sikic BI Journal of Clinical Oncology . 1999,第3期

机译：抗微管蛋白剂的作用机理和耐药性：微管动力学，药物转运和细胞死亡。
4. Effect of Time Strategies on the Profit of Agents Using Adaptive Bid Softness Determination in Continuous Double Auctions with a Fixed Deadline [C] . Huiye Ma, Ho-fung Leung . 2006

机译：在固定截止日期的连续双次拍卖中，时间策略对代理商获利的自适应出价软度确定的影响
5. The double-edged sword: Calcium in life and death. [D] . Ton, Van-Khue T. 2005

机译：双刃剑：生与死中的钙。
6. Cross-linking of T-cell receptors on double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death. [O] . A Lerner, L K Clayton, E Mizoguchi, 1996

机译：T细胞受体在双阳性胸腺细胞上的交联诱导了与细胞死亡有关的细胞因子介导的基质激活过程。
7. BID as a Double Agent in Cell Life and Death [O] . Atan Gross 2006

机译：作为细胞生死和死亡的双重药

BID as a double agent in cell life and death.

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