IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan.

Wallet MA; Wallet SM; Guiulfo G; Sleasman JW; Goodenow MM

首页> 外文期刊>Cellular immunology >IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan.

【24h】

IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan.

机译：IFNγ引发巨噬细胞被高分子量透明质酸激活。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The objective was to assess outcomes of IFNgamma-priming upon macrophage activation by the synovial macromolecule high molecular weight hyaluronan [HMW-HA] in the context of rheumatoid arthritis inflammation. Human macrophages primed by IFNgamma and activated by HMW-HA were evaluated for cytokine secretion by ELISA and Milliplex assay and activation profiles by nuclear transcription factor EIA. IFNgamma-primed, HMW-HA-activated macrophages produced elevated levels of TNF and secreted the TH1 cytokine IL-12p70, while IFNgamma suppressed HMW-HA-induced secretion of the regulatory cytokine IL-10 and activation of the transcription factor c-Jun. IFNgamma modulates the HMW-HA-induced cytokine response profile promoting macrophage activation and inflammatory TH1 cytokine secretion.

机译：目的是评估类风湿关节炎发炎时滑膜大分子高分子量透明质酸[HMW-HA]激活巨噬细胞后IFNγ启动的结果。通过ELISA和Milliplex分析评估由IFNγ引发并被HMW-HA激活的人类巨噬细胞的细胞因子分泌，并通过核转录因子EIA评估其激活概况。 IFNγ引发的HMW-HA活化巨噬细胞产生的TNF水平升高，并分泌TH1细胞因子IL-12p70，而IFNγ抑制HMW-HA诱导的调节性细胞因子IL-10分泌和转录因子c-Jun的激活。 IFNγ调节HMW-HA诱导的细胞因子应答谱，从而促进巨噬细胞激活和炎性TH1细胞因子分泌。

著录项

来源
《Cellular immunology》 |2010年第2期|共5页
作者
Wallet MA; Wallet SM; Guiulfo G; Sleasman JW; Goodenow MM;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞生物学;医学免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan. [J] . Wallet MA, Wallet SM, Guiulfo G, Cellular immunology . 2010,第2期

机译：IFNγ引发巨噬细胞被高分子量透明质酸激活。
2. Chrysophanol demonstrates anti-inflammatory properties in LPS-primed RAW 264.7 macrophages through activating PPAR-gamma [J] . Wen Quan, Mei Liyan, Ye Sen, International immunopharmacology . 2018,第期

机译：Chrysophanol通过激活PPAR-Gamma，表明LPS-Primed Raw 264.7巨噬细胞中的抗炎性质
3. PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. [J] . Bouhlel MA, Derudas B, Rigamonti E, Cell metabolism . 2007,第2期

机译：PPARγ激活可将人单核细胞引发具有抗炎特性的M2巨噬细胞。
4. Hyperosmolar Potassium Depolarization Suppresses Pro-inflammatory Macrophage Activation [C] . Joshua Enrdt-Marino, Hongyu Chen, Mariah S. Hahn Society for Biomaterials annual meeting and exposition . 2019

机译：高渗钾离子去极化抑制促炎性巨噬细胞活化
5. The effects of Cornus officinalis extract on pro-inflammatory markers in lipopolysaccharide (LPS)-activated RAW264.7 macrophages [D] . Akhavan, Neda S. 2014

机译：山茱off提取物对脂多糖（LPS）激活的RAW264.7巨噬细胞促炎标志物的影响
6. IFNγ primes macrophages for inflammatory activation by high molecular weight hyaluronan [O] . Mark A. Wallet, Shannon M. Wallet, Giorgio Guiulfo, -1

机译：IFNγ引发高分子量透明质酸炎症活化的巨噬细胞
7. IFNγ primes macrophages for inflammatory activation by high molecular weight hyaluronan [O] . Department of Pathology, Immunology and Laboratory Medicine, University of Florida, USA ( host institution ), Wallet, Mark A., Wallet, Shannon M., 2010

机译：IFNγ引发巨噬细胞被高分子量透明质酸激活炎症
8. Macrophage Activation to Kill Leishmania tropica: Defective Intracellular Killing of Amastigotes by Macrophages Elicited with Sterile Inflammatory Agents [R] . Hoover, D. L., Nacy, C. A. 1984

机译：巨噬细胞活化杀死利什曼原虫：无菌炎症因子引起的巨噬细胞对无鞭毛体的细胞内杀伤作用的缺陷

IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan.

摘要

著录项

相似文献

相关主题

期刊订阅