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首页> 外文期刊>Cell communication & adhesion >DE-Cadherin, a Core Component of the Adherens Junction Complex Modifies Subcellular Localization of the Drosophila Gap Junction Protein Innexin2
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DE-Cadherin, a Core Component of the Adherens Junction Complex Modifies Subcellular Localization of the Drosophila Gap Junction Protein Innexin2

机译：DE-钙黏着蛋白，粘附连接复合物的核心成分修改果蝇间隙连接蛋白Innexin2的亚细胞定位。

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The Drosophila innexin multigene family of gap junction encoding proteins consists of eight family members whose function in epithelial morphogenesis is mostly unknown. We have recently shown that innexin2 plays a crucial role in the organization of embryonic epithelia. Innexin2 protein accumulates in the epidermis in the apico-lateral membrane domain and colocalizes with core proteins of adherens junctions, such as DE-cadherin and Armadillo, the /5-catenin homolog. Innexin2 localization is altered in both armadillo and DE-cadherin mutants Biochemical interaction studies point to a direct interaction of DE-cadherin and Armadillo with innexin2 suggesting a close link between gap junction and adherens junction biogenesis. We have used the Drosophila Schneider cell tissue culture system to further study the interaction of innexin2 with DE-cadherin. Our results provide evidence that DE-cadherin may be a key component to control trafficking, and localization of Innexin2 to the plasma membrane.
机译：果蝇间隙连接编码蛋白的innexin多基因家族由八个家族成员组成，其在上皮形态发生中的功能几乎是未知的。我们最近显示，innexin2在胚胎上皮组织中起着至关重要的作用。 Innexin2蛋白积聚在apico-外侧膜结构域的表皮中，并与粘附连接的核心蛋白（例如DE-cadherin和犰狳，/ 5-catenin同源物）共定位。 Innexin2在犰狳和DE-cadherin突变体中的定位都发生了改变生化相互作用研究指出，DE-cadherin和Armadillo与innexin2的直接相互作用表明间隙连接和粘附连接生物发生之间的紧密联系。我们已经使用果蝇施耐德细胞组织培养系统来进一步研究innexin2与DE-钙黏着蛋白的相互作用。我们的结果提供证据证明DE-钙粘着蛋白可能是控制运输和Innexin2定位于质膜的关键成分。

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