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首页> 外文期刊>Cell cycle >The novel regulator of metazoan development SAYP organizes a nuclear coactivator supercomplex.
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The novel regulator of metazoan development SAYP organizes a nuclear coactivator supercomplex.

机译：后生动物发展的新型调节剂SAYP可组织核辅活化剂超复合物。

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摘要

SAYP is a dual-function transcription coactivator of RNA polymerase II. It is a metazoan-specific factor with regulated expression that is apparently involved in signaling pathways controlling normal development. In Drosophila, SAYP is maternally loaded into the embryo, participates in cell cycle synchronization in early syncytial embryos, and is indispensible for early embryogenesis. SAYP is abundant in many embryonic tissues and imaginal discs in larvae and is crucial for oogenesis in adults. PHF10 is a mammalian homologue of SAYP whose expression is confined to certain tissues in adults. The molecular mechanism of the SAYP function is related to the conserved domain SAY, which assembles a nuclear supercomplex BTFly consisting of Brahma and TFIID coactivators. We suggest that nuclear supercomplexes may be important means of gene-specific regulation of transcription during development.
机译：SAYP是RNA聚合酶II的双重功能转录共激活因子。它是具有调节表达的后生动物特异性因子，显然参与控制正常发育的信号传导途径。在果蝇中，SAYP被母体装载到胚胎中，参与早期合胞体胚胎中的细胞周期同步，并且对于早期胚胎发生是必不可少的。 SAYP在幼虫的许多胚胎组织和假想椎间盘中都很丰富，对于成人的卵子形成至关重要。 PHF10是SAYP的哺乳动物同源物，其表达仅限于成年人的某些组织。 SAYP功能的分子机制与保守结构域SAY有关，该结构域组装了由梵天和TFIID共激活剂组成的核超复合物BTFly。我们建议核超级复合体可能是发育过程中基因特异性转录调控的重要手段。

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