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Hypoxia: are stem cells in it for the long run?

机译：缺氧：从长远来看，干细胞会存在吗？

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Adult stem cells must persist throughout life to ensure continuous replenishment of dead or damaged cells in various tissues of the body. While numerous studies have already begun to identify some of the factors and mechanisms that regulate long term function and survival of stem cells, there is still much to learn in this regard. A growing body of evidence suggests that various types of stem cells exist in a hypoxic microenvironment, which may be conducive to stem cell longevity. We have recently shown that the oxygen dependent transcription factor hypoxia inducible factor 1alpha (Hif1alpha) is essential for maintenance of functional levels of telomerase in murine embryonic stem cells (mES). Importantly, long-term proliferation of mES cells with reduced Hif1alpha levels led to telomere shortening and ultimately cell senescence. Studies by others over the past 10 years has also indicated that hypoxia and Hif expression are essential for self-renewal and are involved in the regulation of proliferation for some types of stem cells. We now report our view regarding the effects and mechanisms by which hypoxia may regulate the long-term maintenance of stem cell populations.
机译：成年干细胞必须在整个生命中持续存在，以确保不断补充人体各个组织中死亡或受损的细胞。尽管许多研究已经开始确定调节干细胞长期功能和存活的某些因素和机制，但在这方面仍有很多东西要学习。越来越多的证据表明，低氧微环境中存在各种类型的干细胞，这可能有助于干细胞的长寿。我们最近显示，氧依赖性转录因子缺氧诱导因子1alpha（Hif1alpha）对于维持鼠胚胎干细胞（mES）端粒酶功能水平至关重要。重要的是，具有降低的Hif1alpha水平的mES细胞的长期增殖会导致端粒缩短，最终导致细胞衰老。过去10年中其他人的研究也表明，缺氧和Hif表达对于自我更新至关重要，并参与某些类型干细胞的增殖调控。现在，我们就缺氧可能调节干细胞种群的长期维持的作用和机制发表我们的看法。

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