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首页> 外文期刊>Cell cycle >Filamin A stimulates cdc25C function and promotes entry into mitosis.
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Filamin A stimulates cdc25C function and promotes entry into mitosis.

机译：Filamin A刺激cdc25C功能并促进进入有丝分裂。

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摘要

The activity of the dual specificity phosphatase cdc25C is required for mitotic progression though the mechanisms by which cdc25C is activated prior to mitosis in human cells remain unclear. The data presented herein show that the actin binding protein Filamin A forms a complex with cdc25C in vivo and binds preferentially to the mitotic form of cdc25C. Co-expression of Filamin A with cdc25C results in an increase in PCC induced by cdc25C, while knocking down Filamin A expression reduces the levels of PCC induced by cdc25C overexpression. Further, only a Filamin A fragment that forms a complex with both cdc25C and cyclin B1 and retains the dimerization domain can stimulate the ability of cdc25C to induce PCC. These results suggest that Filamin A provides a platform for the assembly of the cyclin B1-cdk1- cdc25C complex resulting in cdk1 activation and mitotic progression.
机译：尽管人细胞中有丝分裂之前cdc25C活化的机制尚不清楚，但双特异性磷酸酶cdc25C的活性对于有丝分裂进程是必需的。本文提供的数据表明肌动蛋白结合蛋白丝蛋白A在体内与cdc25C形成复合物，并优先与cdc25C的有丝分裂形式结合。 Filamin A与cdc25C的共表达会导致cdc25C诱导的PCC增加，而敲低Filamin A的表达则会降低cdc25C过表达诱导的PCC水平。此外，只有与cdc25C和细胞周期蛋白B1形成复合物并保留二聚化结构域的Filamin A片段可以刺激cdc25C诱导PCC的能力。这些结果表明，丝氨酸A为细胞周期蛋白B1-cdk1-cdc25C复合体的组装提供了平台，从而导致cdk1激活和有丝分裂进程。

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