Does Δ133p53 isoform trigger inflammation and autoimmunity?

CampbellH.G.; SlatterT.L.; JeffsA.; MehtaR.; RubioC.; BairdM.; BraithwaiteA.W.

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Does Δ133p53 isoform trigger inflammation and autoimmunity?

机译：Δ133p53亚型会触发炎症和自身免疫吗？

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Autoimmune diseases are characterized by the immune system mounting a response against self. The exact etiology of autoimmune diseases and autoimmunity remain unclear. Here, we demonstrate that Δ133p53, an isoform of the tumor suppressor protein p53, is involved in the development of autoimmunity. We have previously generated a mouse model of Δ133p53 (Δ122p53). Δ122p53 mice develop an autoimmune/inflammation-like phenotype that includes the production of autoantibodies, elevated levels of pro-inflammatory cytokines and lymphocyte aggregations in various organs. Microarray analysis reveals that expression of Δ122p53 induces a number of pro-inflammatory genes, including the STAT1 pathway and interferon-related transcription profile. Comparative genetic signatures have been observed in human SLE (systemic lupus erythematosus) patients, and we show that Δ133p53 regulates STAT1 in human cells. Our findings provide the first evidence of a role for p53 isoforms in the development of autoimmune disease.

机译：自身免疫性疾病的特征是免疫系统对自身反应增强。自身免疫疾病和自身免疫的确切病因仍不清楚。在这里，我们证明了抑癌蛋白p53的亚型Δ133p53参与了自身免疫的发展。我们之前已经生成了Δ133p53（Δ122p53）的小鼠模型。 Δ122p53小鼠发展出自身免疫/炎症样表型，其中包括自身抗体的产生，促炎细胞因子水平的升高以及各个器官中淋巴细胞的聚集。微阵列分析表明，Δ122p53的表达诱导了许多促炎基因，包括STAT1途径和干扰素相关的转录谱。在人类SLE（系统性红斑狼疮）患者中观察到了比较的遗传特征，我们显示出Δ133p53调节人类细胞中的STAT1。我们的发现为p53亚型在自身免疫性疾病发展中的作用提供了第一个证据。

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《Cell cycle》 |2012年第3期|共5页
作者
CampbellH.G.; SlatterT.L.; JeffsA.; MehtaR.; RubioC.; BairdM.; BraithwaiteA.W.;
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正文语种 eng
中图分类细胞生物学;
关键词
Autoimmune; Delta133p53; Inflammation; P53; P53 isoforms;

机译：自身免疫;Delta133p53;炎症;P53;P53亚型;

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1. Does Δ133p53 isoform trigger inflammation and autoimmunity? [J] . CampbellH.G., SlatterT.L., JeffsA., Cell cycle . 2012,第3期

机译：Δ133p53亚型会触发炎症和自身免疫吗？
2. Elevation of the TP53 TP53 isoform Δ133p53β Δ133p53β in glioblastomas: an alternative to mutant p53 in promoting tumor development [J] . Kazantseva Marina, Eiholzer Ramona A, Mehta Sunali, Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland . 2018,第1期

机译：胶质细胞瘤中TP53 TP53同种δ1333P53βδ133P53β的升高：突变P53促进肿瘤发育的替代品
3. Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity [J] . BruscaS.B., AbramsonS.B., ScherJ.U. Current opinion in rheumatology . 2014,第1期

机译：微生物组和粘膜炎症是类风湿关节炎和自身免疫的关节外诱因
4. Expression of genes involved in stress, toxicity, inflammation, and autoimmunity, and levels of heavy metals in human blood [C] . R. Monastero, C. Vacchi-Suzzi, C. Marsit, Annual conference of the International Society of Exposure Science . 2017

机译：涉及压力，毒性，炎症和自身免疫的基因表达以及人血中的重金属含量
5. Structural and functional characterization of novel mimicry epitopes as potential triggers of multiple sclerosis and heart autoimmunity. [D] . Massilamany, Chandirasegaran. 2013

机译：新型模仿表位的结构和功能表征是多发性硬化症和心脏自身免疫的潜在诱因。
6. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1 MyD88 and a microbial trigger [O] . Ben A. Croker, Brian R. Lawson, Michael Berger, 2008

机译：SHP1突变引起的炎症和自身免疫取决于IL-1MyD88和微生物触发
7. Silica Triggers Inflammation and Ectopic Lymphoid Neogenesis in the Lungs in Parallel with Accelerated Onset of Systemic Autoimmunity and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse. [O] . Melissa A Bates, Christina Brandenberger, Ingeborg Langohr, 2015

机译：在Lupus-prone NZBWF1小鼠中，二氧化硅引起肺部炎症和异位淋巴新生，并伴有系统性自身免疫和肾小球肾炎的加速发作。

Does Δ133p53 isoform trigger inflammation and autoimmunity?

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