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首页> 外文期刊>Reproduction in Domestic Animals >The role of oocyte-secreted factors GDF9 and BMP15 in follicular development and oogenesis. [Review]
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The role of oocyte-secreted factors GDF9 and BMP15 in follicular development and oogenesis. [Review]

机译：卵母细胞分泌因子GDF9和BMP15在卵泡发育和卵子发生中的作用。 [评论]

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摘要

Ovarian physiology is controlled by endocrine and paracrine signals, and the transforming growth factor beta (TGFbeta) superfamily has a pivotal role in this control. The Bone morphogenetic protein 15 (BMP15) and Growth differentiation factor 9 (GDF9) genes are relevant members of the TGFbeta superfamily that encode proteins secreted by the oocytes into the ovarian follicles. Through a paracrine signalling pathway, these factors induce the follicular somatic cells to undergo mitosis and differentiation during follicular development. These events are controlled by a mutually dependent and coordinated fashion during the formation of the granulosa cell layers. Many studies have contributed to our knowledge concerning the paracrine factors acting within the follicular environment, especially regarding GDF9 and BMP15. We aimed to review the relevant contributions of these two genes to animal reproductive physiology
机译：卵巢生理受内分泌和旁分泌信号控制，而转化生长因子β（TGFbeta）超家族在这种控制中起着关键作用。骨形态发生蛋白15（BMP15）和生长分化因子9（GDF9）基因是TGFbeta超家族的相关成员，它们编码卵母细胞分泌到卵泡中的蛋白。通过旁分泌信号传导途径，这些因子诱导卵泡体细胞在卵泡发育过程中发生有丝分裂和分化。这些事件在颗粒细胞层形成过程中以相互依赖和协调的方式控制。许多研究有助于我们了解在卵泡环境中起作用的旁分泌因子，尤其是有关GDF9和BMP15的知识。我们旨在审查这两个基因对动物生殖生理的相关贡献。

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