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Born to survive: Autophagyin hematopoietic stem cell maintenance

机译：为生存而生：自噬因子造血干细胞维持

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摘要

Hematopoietic stem cells (HSCs) are unique in their ability to self-renew and produce all mature blood cells. Thus, HSCs are central for the lifelong maintenance of the blood system, and considerable evidence suggests that HSCs are equipped with unique survival mechanisms that ensure their protection throughout life. These include localization to specialized hypoxic niches in the bone marrow (BM) cavity and maintenance of HSCs in a quiescent, slow cycling state. However, these strategies primarily function to minimize stress and production of damaging reactive oxygen species (ROS) associated with replication and cellular respiration. In contrast, less is known about the mechanisms used by HSCs to cope with stresses occurring in the BM cavity. Recently, we showed that HSCs could survive metabolic stress by inducing a robust protective autophagy response.
机译：造血干细胞（HSC）具有自我更新和产生所有成熟血细胞的能力。因此，HSC对血液系统的终生维护至关重要，大量证据表明，HSC具有独特的生存机制，可确保其终生保护。这些措施包括定位到骨髓（BM）腔中的特定缺氧小生境，以及将HSC维持在静态，缓慢的循环状态。但是，这些策略的主要作用是最大程度地减少与复制和细胞呼吸有关的压力和破坏性活性氧（ROS）的产生。相反，对于HSC用来应对BM腔中出现的应力的机制知之甚少。最近，我们表明，HSCs可以通过诱导强大的保护性自噬反应来抵抗代谢应激。

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