...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Reproduction, fertility, and development >Nutrition and maternal metabolic health in relation to oocyte and embryo quality: critical views on what we learned from the dairy cow model
【24h】

Nutrition and maternal metabolic health in relation to oocyte and embryo quality: critical views on what we learned from the dairy cow model

机译：营养和母体代谢健康与卵母细胞和胚胎质量的关系：对我们从奶牛模型中学到的批评

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although fragmented and sometimes inconsistent, the proof of a vital link between the importance of the physiological status of the mother and her subsequent reproductive success is building up. High- yielding dairy cows are suffering from a substantial decline in fertility outcome over past decades. For many years, this decrease in reproductive output has correctly been considered multifactorial, with factors including farm management, feed ratios, breed and genetics and, last, but not least, ever- rising milk production. Because the problem is complex and requires a multidisciplinary approach, it is hard to formulate straightforward conclusions leading to improvements on the ` work floor'. However, based on remarkable similarities on the preimplantation reproductive side between cattle and humans, there is a growing tendency to consider the dairy cow's negative energy balance and accompanying fat mobilisation as an interesting model to study the impact of maternal metabolic disorders on human fertility and, more specifically, on oocyte and preimplantation embryo quality. Considering the mutual interest of human and animal scientists studying common reproductive problems, this review has several aims. First, we briefly introduce the ` dairy cow case' by describing the state of the art of research into metabolic imbalances and their possible effects on dairy cow reproduction. Second, we try to define relevant in vitro models that can clarify certain mechanisms by which aberrant metabolite levels may influence embryonic health. We report on recent advances in the assessment of embryo metabolism and meantime critically elaborate on advantages and major limitations of in vitro models used so far. Finally, we discuss hurdles to be overcome to successfully translate the scientific data to the field.
机译：尽管支离破碎，有时甚至不一致，但母亲生理状态的重要性与其随后的生殖成功之间至关重要的联系的证据正在建立。在过去的几十年中，高产奶牛的生育能力大幅下降。多年以来，生殖产量的下降被正确地认为是多因素的，其因素包括农场管理，饲料比例，品种和遗传，最后但并非最不重要的是牛奶产量不断增加。因为问题很复杂并且需要多学科的方法，所以很难得出直接的结论以导致“工作现场”的改善。然而，基于牛与人之间在植入前生殖方面的显着相似性，越来越多的趋势将奶牛的负能量平衡和伴随脂肪动员作为研究母体代谢异常对人类生育力影响的有趣模型，并且更具体地说，关于卵母细胞和植入前胚胎的质量。考虑到人类和动物科学家研究共同的生殖问题的共同利益，本综述有几个目的。首先，我们通过描述关于代谢失衡及其对奶牛繁殖的可能影响的研究现状，简要介绍“奶牛病例”。其次，我们尝试定义相关的体外模型，以阐明异常代谢物水平可能影响胚胎健康的某些机制。我们报告评估胚胎代谢的最新进展，同时严格阐述迄今为止使用的体外模型的优势和主要局限性。最后，我们讨论了要成功地将科学数据转换到现场需要克服的障碍。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号