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首页> 外文期刊>Cell cycle >Wnts as essential growth factors for the adult small intestine and colon.
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Wnts as essential growth factors for the adult small intestine and colon.

机译：Wnts是成年小肠和结肠的重要生长因子。

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The study of physiologic functions of Wnt proteins has been complicated by the redundant nature of the families encoding the Wnt factors and their Frizzled receptors. Adenoviral expression of the secreted Wnt antagonist Dickkopf-1 (Dkk1) was used to achieve fully conditional inhibition of canonical Wnt signaling in adult mice. Systemic expression of Dkk1 resulted in rapid inhibition of Wnt target gene expression and of proliferation of the small intestine and colon, loss of proliferative crypts, and eventual inflammation and architectural degeneration. These studies indicate an essential requirement for extracellular Wnt signaling in the maintenance of adult small intestine and colon proliferation. The essential role of Wnt signaling in ongoing proliferation in the colon suggests potential clinical applications in mucosal repair for inflammatory bowel diseases and underscores the utility of adenoviral strategies for conditional ablation of gene function in adult organisms.
机译：Wnt蛋白的生理功能研究由于编码Wnt因子及其卷曲蛋白受体的家族的冗余性质而变得复杂。分泌的Wnt拮抗剂Dickkopf-1（Dkk1）的腺病毒表达可用于完全抑制成年小鼠经典Wnt信号的表达。 Dkk1的系统性表达导致Wnt靶基因表达的快速抑制和小肠和结肠的增殖，增生性隐窝的丢失以及最终的炎症和结构退化。这些研究表明在维持成年小肠和结肠增殖中细胞外Wnt信号传导的基本要求。 Wnt信号在结肠中持续增殖中的重要作用提示在炎症性肠疾病的粘膜修复中的潜在临床应用，并强调了腺病毒策略在成人生物体中有条件消融基因功能的实用性。

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