• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell communication & adhesion >Astrocyte and Oligodendrocyte Connexins of the Glial Syncytium in Relation to Astrocyte Anatomical Domains and Spatial Buffering
【24h】

Astrocyte and Oligodendrocyte Connexins of the Glial Syncytium in Relation to Astrocyte Anatomical Domains and Spatial Buffering

机译：胶质合胞体的星形胶质细胞和少突胶质细胞连接蛋白与星形胶质细胞的解剖结构域和空间缓冲有关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Astroctyes express a set of three connexins (Cx26, Cx30, and Cx43) that are contained in astrocyte-to-astrocyte (A/A) gap junctions; oligodendrocytes express a different set of three connexins (Cx29, Cx32, and Cx47) that are contained in the oligodendrocyte side of necessarily heterotypic astrocyte-to-oligodendrocyte (A/0) gap junctions, and there is little ultrastructural evidence for gap junction formation between individual oligodendrocytes. In addition, primarily Cx29 and Cx32 are contained deeper in myelin sheaths, where they form autologous gap junctions at sites of uncompacted myelin. The presence of six connexins in macroglial cell populations has revealed unprecedented complexity of potential connexin coupling partners, and with restricted deployment of gap junctional intercellular communication (GJIC) within the "pan-glial" syncytium. New implications for the organization and regulation of spatial buffering mediated by glial GJIC are derived from recent observations of the existence of separate astrocyte anatomical domains, with only narrow regions of overlap between astrocyte processes at domain borders. Thus, widespread spatial buffering in the CMS may occur not successively through a multitude of processes arising from different astrocytes, but rather in a more orderly fashion from one astrocyte domain to another via intercellular coupling that occurs only at restricted regions of overlap between astrocyte domains, augmented by autocellular coupling that occurs within each domain.
机译：星形胶质细胞表达星形胶质细胞与星形胶质细胞（A / A）间隙连接中包含的三种连接蛋白（Cx26，Cx30和Cx43）的集合。少突胶质细胞表达不同的三种连接蛋白（Cx29，Cx32和Cx47），它们包含在必然为异型星形胶质细胞与少突胶质细胞（A / 0）之间的间隙连接的少突胶质细胞侧，并且几乎没有超结构证据表明之间存在间隙连接单个少突胶质细胞。此外，Cx29和Cx32主要包含在髓鞘中较深的位置，它们在未压实的髓磷脂部位形成自体间隙连接。大胶质细胞群中六种连接蛋白的存在揭示了潜在的连接蛋白偶联伙伴前所未有的复杂性，并且在“泛神经胶质”合胞体中间隙连接细胞间通讯（GJIC）的部署受到限制。由神经胶质GJIC介导的空间缓冲的组织和调节的新含义来自最近观察到的单独星形胶质细胞解剖结构域的存在，在域边界处星形胶质细胞突之间只有狭窄的重叠区域。因此，CMS中广泛的空间缓冲可能不是通过不同的星形胶质细胞产生的多个过程连续发生，而是通过仅在星形胶质细胞结构域之间重叠的受限区域发生的细胞间偶联，从一个星形胶质细胞域到另一个星形胶质细胞域以更有序的方式发生，通过在每个结构域内发生的自身细胞偶联而增强。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号