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首页> 外文期刊>Cell cycle >Transcriptional targeting by microRNA-Polycomb complexes: A novel route in cell fate determination
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Transcriptional targeting by microRNA-Polycomb complexes: A novel route in cell fate determination

机译：microRNA-Polycomb复合物的转录靶向：确定细胞命运的新途径

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Advances in the understanding of the epigenetic events underlying the regulation of developmental genes expression and cell lineage commitment are revealing novel regulatory networks. These also involve distinct components of the epigenetic pathways, including chromatin histone modification, DNA methylation, repression by polycomb complexes and microRNAs. Changes in chromatin structure, DNA methylation status and microRNA expression levels represent flexible, reversible and heritable mechanisms for the maintenance of stem cell states and cell fate decisions. We recently provided novel evidence showing that microRNAs, besides determining the post-transcriptional gene silencing of their targets, also bind to evolutionarily conserved complementary genomic seed-matches present on target gene promoters. At these sites, microRNAs can function as a critical interface between chromatin remodeling complexes and the genome for transcriptional gene silencing. Here, we discuss our novel findings supporting a role of the transcriptional chromatin targeting by polycomb-microRNA complexes in lineage fate determination of human hematopoietic cells.
机译：在对发育基因表达和细胞谱系定型调控基础的表观遗传事件的理解上的进展揭示了新型的调控网络。这些还涉及表观遗传途径的不同组成部分，包括染色质组蛋白修饰，DNA甲基化，多梳复合物和microRNA的抑制。染色质结构，DNA甲基化状态和microRNA表达水平的变化代表了维持干细胞状态和细胞命运决定的灵活，可逆和可遗传的机制。我们最近提供了新的证据，显示除确定其靶标的转录后基因沉默外，microRNA还与存在于靶标基因启动子上的进化上保守的互补基因组种子匹配相结合。在这些位点，microRNA可以充当染色质重塑复合体与基因组之间的关键界面，从而使转录基因沉默。在这里，我们讨论了我们的新发现，这些新发现支持通过多梳-microRNA复合物靶向转录染色质在人类造血细胞谱系命运确定中的作用。

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