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首页> 外文期刊>Liver international : >Trafficking of recirculating lymphocytes in the rat liver: rapid transmigration into the portal area and then to the hepatic lymph.
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Trafficking of recirculating lymphocytes in the rat liver: rapid transmigration into the portal area and then to the hepatic lymph.

机译：在大鼠肝脏中贩运再循环淋巴细胞：迅速转移到门静脉区域，然后转移到肝淋巴。

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BACKGROUND: We have investigated how recirculating lymphocytes patrol the liver in a normal steady state. METHODS: Thoracic duct lymphocytes of congeneic rats were intravenously transferred to host rats and donor cell trafficking in the liver and hepatic lymph was examined. Host hepatic lymph nodes (HLNs) were selectively removed, which allowed liver-derived donor cells to collect in the thoracic duct without transit in the intervening HLNs. RESULTS: The number of donor cells in the thoracic duct lymph significantly increased over the baseline 3, 5 and 11 h after transfer in the HLN-removed, non-pretreated, and HLN-ligated (in which a lymph efflux was blocked) groups, respectively. Histologically, donor cells appeared in the portal area from 0.5 h after transfer and frequently attached to the basal lamina of portal vein both externally and internally. Three hours after transfer, a few donor cells appeared in the subcapsular sinus of HLNs. CONCLUSION: The minimal transit time of rat recirculating lymphocytes is 3-4 h in the liver and 5-8 h in the hepatic LNs, in a normal steady state. Recirculating lymphocytes might transmigrate through the portal vein as well as the sinusoid in the periportal zone. This rapid transit might enable an efficient surveillance of the liver portal area by the recirculating lymphocytes.
机译：背景：我们研究了正常状态下循环淋巴细胞如何在肝脏中巡逻。方法：将同系大鼠的胸导管淋巴细胞静脉内转移至宿主大鼠，检查肝和肝淋巴中供体细胞的运输情况。选择性地去除宿主肝淋巴结（HLN），这使得肝源性供体细胞可以收集在胸导管中，而无需在介入的HLN中转运。结果：在转移后的3、5和11小时内，在HLN切除，未预处理和HLN结扎（其中淋巴流出被阻止）组中，胸导管淋巴中的供体细胞数量显着增加，分别。组织学上，供体细胞从转移后0.5小时开始出现在门区，并在外部和内部频繁附着在门静脉的基底层上。转移三小时后，HLNs的囊下窦出现了一些供体细胞。结论：正常状态下，大鼠循环淋巴细胞在肝脏中的最小转运时间为3-4h，在肝LNs中的最小转运时间为5-8h。再循环的淋巴细胞可能会通过门静脉以及门静脉区的正弦波迁移。这种快速通过可能使再循环的淋巴细胞有效监测肝门区域。

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