PTEN sumo-wrestles human RAD52 to mystery land

ShenZ.; HuhnS.

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PTEN sumo-wrestles human RAD52 to mystery land

机译：PTEN相扑人类RAD52闯入神秘土地

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The PTEN gene was initially known as a gatekeeper tumor suppressor that inhibits the growth signaling mediated by phospha-tidylinositol-3,4,5-trisphosphate. It is now recognized that PTEN also acts as a caretaker to maintain genomic stability. The precise mechanisms by which PTEN regulates genomic stability remain elusive, but several possibilities exist. It localizes to chromosome centromeres and regulates RAD51 recruitment to DNA damage sites. A fraction of nuclear PTEN is sumoylated at lysine-254.

机译：PTEN基因最初被称为“守门人”肿瘤抑制因子，其抑制由磷酸-tidylinositol-3,4,5-三磷酸酯介导的生长信号。现在已经认识到，PTEN还可以充当看护人以维持基因组稳定性。 PTEN调节基因组稳定性的精确机制仍然难以捉摸，但是存在几种可能性。它定位于染色体着丝粒并调节RAD51募集至DNA损伤位点。一部分核PTEN在赖氨酸254处被磺酰化。

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《Cell cycle》 |2013年第23期|共1页
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ShenZ.; HuhnS.;
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正文语种 eng
中图分类细胞生物学;
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1. PTEN sumo-wrestles human RAD52 to mystery land [J] . ShenZ., HuhnS. Cell cycle . 2013,第23期

机译：PTEN相扑人类RAD52闯入神秘土地
2. 15-Deoxy-Delta(12,14)-prostaglandin J(2) activates PI3K-Akt signaling in human breast cancer cells through covalent modification of the tumor suppressor PTEN at cysteine 136 [J] . Suh Jinyoung, Kim Do-Hee, Kim Eun-Hee, Cancer letters . 2018,第期

机译：15-DEOXY-DELTA（12,14） - PROSTAGLAGININ J（2）通过在半胱氨酸136的肿瘤抑制剂PTEN的共价修饰激活人乳腺癌细胞中的PI3K-AKT信号传导
3. Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma. [J] . Diegel CR, Cho KR, El Naggar AK, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2010,第22期

机译：小鼠唾液腺中Apc和Pten失活后，雷帕霉素依赖性腺泡细胞瘤形成的哺乳动物靶点：对人腺泡细胞癌的影响。
4. Tumor Suppression by Glucosylated Polyethylenimine (GPEI)/PTEN complex Delivery through Aerosoland Intravenous Routes [C] . In-Kyu Park, Hyun-Woo Kim, Myung-Haing Cho, Annual meeting exposition of the Controlled Release Society . 2005

机译：糖基化聚乙烯亚胺（GPEI）/ PTEN复合物通过Aerosoland静脉内途径抑制肿瘤。
5. Molecular Characterization of a RAD51-independent Conservative Homologous Recombination Mechanism Driven by Human RAD52 in the Model Organism Saccharomyces cerevisiae [D] . Clear, Alissa Denise. 2018

机译：用人Rad52在模型生物体酿酒酵母中驱动的Rad51独立保守同源重组机制的分子表征
6. PTEN sumo-wrestles human RAD52 to mystery land [O] . Zhiyuan Shen, Steven Huhn 2013

机译：PTEN相扑将人类RAD52扑向神秘土地
7. PTEN sumo-wrestles human RAD52 to mystery land [O] . Zhiyuan Shen 2013

机译：PTEN SUMO-WRESTLES人RAD52到神秘的土地
8. Towards an Atomic Understanding of Double-Strand Break Repair: Crystal Structure of Human RAD52 Protein [R] . Ranatunga, W. K. , Borgstahl, G. 2002

机译：对双链断裂修复的原子理解：人RaD52蛋白的晶体结构

PTEN sumo-wrestles human RAD52 to mystery land

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